摘要
干眼症是最常见的眼表疾病之一,其发病多与泪液过度蒸发有关,而后者常由睑板腺功能障碍引起。在蒸发过强型干眼症患者中,泪膜脂质层存在缺陷,导致泪液蒸发速率增加,进而引发眼表炎症和组织损伤。目前,干眼的治疗手段多集中于促进泪液分泌或抑制眼表炎症,却往往未能针对泪液过度蒸发的根本原因进行干预。全氟己基辛烷滴眼液是一种无水、成分单一且不含防腐剂的处方眼药水,能够直接针对泪液过度蒸发的核心病理环节发挥作用。该药物具有良好的携氧能力,可减轻眼睑与眼表之间的摩擦,并能在泪膜表面迅速铺展,形成一层稳定的脂质样屏障,有效抑制水分蒸发。这一机制不仅有助于泪膜稳定,还能促进眼表上皮的修复与愈合。本文旨在对全氟己基辛烷滴眼液的作用机制,临床有效性、安全性及不良反应等方面的研究进展进行系统综述。
Dry eye syndrome is one of the most common ocular surface diseases,primarily associated with excessive tear evaporation,which is often caused by meibomian gland dysfunction.In patients with evaporative dry eye,defects in the tear film lipid layer lead to increased tear evaporation rates,subsequently triggering ocular surface inflammation and tissue damage.Current treatments for dry eye mainly focus on promoting tear secretion or suppressing ocular surface inflammation,but often fail to address the root cause of excessive tear evaporation.Perfluorohexyloctane eye drops are an anhydrous,single-component,preservative-free prescription ophthalmic solution that directly targets the core pathological mechanism of excessive tear evaporation.This drug exhibits excellent oxygen-carrying capacity,reduces friction between the eyelids and the ocular surface,and rapidly spreads across the tear film surface to form a stable lipid-like barrier,effectively inhibiting water evaporation.This mechanism not only helps stabilize the tear film but also promotes the repair and healing of the ocular surface epithelium.This article aims to provide a systematic review of the research progress on the mechanism of action,clinical efficacy,safety,and adverse effects of perfluorohexyloctane eye drops.
作者
闻郁
刘勇
刘帅帅
WEN Yu;LIU Yong;LIU Shuaishuai(Anhui Aier Eye Hospital of Anhui Medical University,Hefei 241313,Anhui Province,China)
出处
《眼科新进展》
北大核心
2026年第2期165-168,共4页
Recent Advances in Ophthalmology
基金
国家自然科学基金(编号:82360955)
甘肃省省级人才重点项目[编号:甘组通字(2024)4号]
甘肃省名中医罗向霞传承工作室建设项目(编号:250031)。
关键词
全氟己基辛烷
干眼
睑板腺功能障碍
泪膜
脂质层
perfluorohexyloctane
dry eye
meibomian gland dysfunction
tear film
lipid layer
