摘要
目的探讨术前血清促血管生成素(Ang-2)、半乳糖凝集素3(Gal-3)水平在非小细胞肺癌(NSCLC)患者胸腔镜术后预后评估中的预测价值。方法收集无锡市锡山人民医院收治的2019年1月至2021年1月行胸腔镜切除术的NSCLC患者92例为研究对象,根据随访结果分为复发组(n=34)和非复发组(n=58)。血清Ang-2、Gal-3水平检测用ELISA法,NSCLC患者血清中Ang-2与Gal-3水平之间的相关性用Pearson法分析;Logistic回归分析影响NSCLC患者预后的相关因素;受试者操作特征曲线(ROC曲线)评估血清Ang-2、Gal-3水平对NSCLC患者预后的预测价值。结果与非复发组相比,复发组血清Ang-2、Gal-3水平均升高(P<0.05)。Pearson相关性分析结果显示,NSCLC患者血清Ang-2与Gal-3水平之间存在明显的正相关关系(r=0.503,P<0.001)。复发组和非复发组患者是否有吸烟史、是否有神经侵犯、是否有血管侵袭、病理类型、年龄、手术中出血量、手术时间比较,差异无统计学意义(P>0.05),TNM分期、分化程度比较,差异有统计学意义(P<0.05)。TNM分期,分化程度,血清Ang-2、Gal-3水平均是NSCLC患者术后复发的影响因素(P<0.05)。血清Ang-2、Gal-3二者联合预测NSCLC患者预后的AUC为0.965,敏感度为88.24%,特异度为98.28%,优于Ang-2、Gal-3单独预测(Z_(二者联合-Ang-2)=3.221、P=0.001,Z_(二者联合-Gal-3)=2.063、P=0.039)。结论在NSCLC患者中,血清Ang-2、Gal-3水平均升高,且可以作为评估NSCLC患者胸腔镜切除术后预后的辅助血清标志物。
Objective To explore the predictive value of preoperative serum levels of angiopoietin(Ang-2)and galactin-3(Gal-3)in the prognosis evaluation of non-small cell lung cancer(NSCLC)patients after thoracoscopic.Method A total of 92 NSCLC patients who underwent thoracoscopic from January 2019 to January2021 in our hospital were regarded as the study subjects.According to the follow-up results,they were separated into a recurrent group(n=34)and a non recurrent group(n=58).Serum Ang-2 and Gal-3 levels were detected using ELISA method.The correlation between Ang-2 and Gal-3 levels in the serum of NSCLC patients was analyzed using Pearson's method.Logistic regression was applied to analyze the relevant factors affecting the prognosis of NSCLC patients.ROC curve was applied to evaluate the predictive value of serum Ang-2 and Gal-3 levels for the prognosis of NSCLC patients.Result Compared with the non recurrent group,the serum Ang-2 and Gal-3 level in the recurrent group increased(P<0.05).Pearson correlation analysis results showed a obvious positive correlation between serum Ang-2and Gal-3 levels in NSCLC patients(r=0.503,P<0.001).There were no significant differences in smoking history,presence of nerve invasion,presence of vascular invasion,pathological type,age,intraoperative blood loss,or operation time between the recurrence group and the non-recurrence group(P>0.05).However,there was a obvious difference(P<0.05)in TNM staging and differentiation degree.TNM staging,differentiation degree,serum Ang-2 and Gal-3 levels were all influencing factors for postoperative recurrence in NSCLC patients(P<0.05).The combined prediction of serum Ang-2 and Gal-3 for the prognosis of NSCLC patients had an AUC of 0.965,sensitivity of 88.24%,and specificity of 98.28%,which was better than Ang-2and Gal-3 alone prediction(Z_(combination-Ang-2)=3.221,P=0.001,Z_(combination-Gal-3)=2.063,P=0.039.Conclusion In NSCLC patients,serum Ang-2 and Gal-3 levels are elevated and can serve as auxiliary serum markers for evaluating the prognosis of thoracoscopic in NSCLC patients.
作者
顾家榕
王新连
俞峥
陆斌
赵锭婷
Gu Jiarong;Wang Xinlian;Yu Zheng;Lu Bin;Zhao Dingting(Department of Thoracic Surgery,Xishan People's Hospital,Wuxi 214000,Jiangsu,China;Department of Laboratory,Wuxi Xishan People's Hospital,Wuxi 214000,Jiangsu,China)
出处
《肿瘤代谢与营养电子杂志》
2025年第5期602-608,共7页
Electronic Journal of Metabolism and Nutrition of Cancer
