摘要
目的分析宫颈高危型人乳头瘤病毒(HPV)感染患者血清白细胞介素6(IL-6)、肿瘤坏死因子(TNF)的表达水平。方法选取2020年10月1日至2023年12月31日四川省江油市第二人民医院妇科门诊收治的宫颈高危型HPV感染患者1000例,分析患者感染的HPV分型,比较不同分型患者及不同宫颈病变患者血清IL-6、TNF表达的差异。结果1000例宫颈高危型HPV感染患者中检出4种高危HPV型别(16、18、58、52),其中感染HPV16的患者302例,占30.2%;感染HPV18的患者417例,占41.7%。不同分型的高危型HPV感染患者血清IL-6、TNF的表达水平比较,差异无统计学意义(P>0.05)。302例感染HPV16的患者中,根据宫颈病变情况进行分组,其中无宫颈病变者65例、低级别鳞状上皮内病变(LSIL)患者112例、高级别鳞状上皮内病变(HSIL)患者99例、宫颈癌患者26例,4组患者血清IL-6、TNF的表达水平比较,差异有统计学意义(P<0.05)。417例感染HPV18的患者中,根据宫颈病变情况进行分组,其中无宫颈病变者155例、LSIL患者132例、HSIL患者101例、宫颈癌患者29例,4组患者血清IL-6、TNF的表达水平比较,差异有统计学意义(P<0.05)。结论HPV16或HPV18感染患者血清IL-6、TNF水平与宫颈病变的程度有关。HPV16或HPV18感染患者血清IL-6、TNF的表达情况可能作为预测宫颈癌的有效筛查指标。
Objective To analyze the expression levels of serum interleukin-6(IL-6)and tumor necrosis factor(TNF)in patients with high-risk cervical human papillomavirus(HPV)infection.Methods A total of 1000 patients with high-risk HPV infection who were treated at the Gynecological Clinic of Jiangyou Second Peoples Hospital from October 1,2020,to December 31,2023 were enrolled in this study.The distribution of high-risk HPV subtypes in all patients was analyzed,and serum levels of IL-6 and TNF were compared among patients with different HPV subtypes.The expression levels of serum IL-6 and TNF in patients with different cervical lesions caused by HPV16 and/or HPV18 were also compared.Results Four types of high-risk HPV(16,18,58,52)were detected from the 1000 patients.Among them,302(30.2%)were infected with HPV16,and 417(41.7%)were infected with HPV18.There was no significant difference in the expression levels of serum IL-6 or TNF among patients with different high-risk HPV infections(P>0.05).In those infected with HPV16,there were 65 patients without lesions,112 patients with low-grade squamous intraepithelial lesions(LSIL),99 patients with high-grade squamous intraepithelial lesions(HSIL),and 26 patients with cervical cancer.In those infected with HPV18,there were 155 patients without lesions,132 patients with LSIL,101 patients with HSIL,and 29 patients with cervical cancer.There were significant differences in the expression levels of serum IL-6 and TNF among patients with different cervical lesions caused by HPV16 or HPV18(P<0.05).Conclusion The risk of cervical lesions may increase in patients infected with HPV16 or HPV18 by elevating serum IL-6 and TNF levels,and the lesions even develop into cervical cancer.Therefore,the expression of serum IL-6 and TNF in patients infected with HPV16 or HPV18 may serve as an effective indicator for predicting cervical cancer.
作者
田冬梅
王斐
Tian Dongmei;Wang Fei(Department of Obstetrics and Gynecology,Jiangyou Second People’s Hospital,Jiangyou 621700,China)
出处
《海军医学杂志》
2026年第1期29-32,共4页
Journal of Navy Medicine
基金
四川省科技厅重点研发项目(2022YFS0242)。
