摘要
目的:探讨甘油三酯-葡萄糖(TyG)指数对多囊卵巢综合征(PCOS)患者体外受精/卵母细胞胞质内单精子注射(IVF/ICSI)助孕结局的影响。方法:选取2023年9月至2024年12月在本院生殖医学科首次接受IVF/ICSI治疗的64例PCOS患者作为研究对象,根据TyG值分为低TyG组(n=42,TyG≤8.65)和高TyG组(n=22,TyG>8.65),比较其临床资料及助孕结局,探讨TyG与助孕结局的关系。结果:低TyG组和高TyG组年龄、不孕病程、体质量指数、GN使用量、GN使用天数、AFC、bFSH、注射HCG日子宫内膜厚度、获卵数、正常受精数对比,差异无统计学意义(P>0.05);高TyG组D3优质胚胎数低于低TyG组(P<0.05);低TyG组的分娩率80.95%高于高TyG组54.55%(P<0.05)。Logistic逐步回归分析,相对于高TyG组,TyG≤8.65是患者分娩的保护因素(OR=5.589,95%CI:1.145~24.157,P<0.05)。结论:TyG≤8.65是PCOS患者IVF/ICSI治疗后成功分娩的保护因素,临床应关注PCOS患者的TyG表达情况,尽早对TyG高表达者采取针对性干预措施,以提高分娩率,改善助孕结局。
Objective:To investigate the impact of the Triglyceride-Glucose(TyG)index on in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)outcomes in patients with polycystic ovary syndrome(PCOS).Methods:A total of 64 PCOS patients who underwent their first IVF/ICSI treatment at our reproductive medicine department from September 2023 to December 2024 were selected as the study subjects.They were divided into a low-TyG group(n=42,TyG≤8.65)and a high-TyG group(n=22,TyG>8.65)based on their TyG values.Clinical data and assisted reproductive outcomes were compared between the two groups to explore the relationship between TyG and IVF/ICSI outcomes.Results:No statistically significant differences were observed between the low-TyG and high-TyG groups in terms of age,duration of infertility,body mass index(BMI),total gonadotropin(GN)dosage,duration of GN stimulation,antral follicle count(AFC),basal follicle-stimulating hormone(bFSH)level,endometrial thickness on the day of human chorionic gonadotropin(hCG)trigger,number of oocytes retrieved,and number of normally fertilized oocytes(all P>0.05).However,the number of high-quality embryos on day 3 was significantly lower in the high-TyG group compared to the low-TyG group(P<0.05).Furthermore,the live birth rate in the low-TyG group was significantly higher than that in the high-TyG group(80.95%vs.54.55%,P<0.05).Stepwise logistic regression analysis revealed that,compared to the high-TyG group,a TyG level≤8.65 was a protective factor for live birth(OR=5.589,95%CI:1.145~24.157,P<0.05).Conclusion:A TyG index≤8.65 is a protective factor for successful live birth following IVF/ICSI treatment in PCOS patients.Clinicians should pay attention to the TyG levels in PCOS patients and implement targeted interventions as early as possible for those with elevated TyG to improve live birth rates and overall assisted reproductive outcomes.
作者
梁祺
江莉
Liang Qi;Jiang Li(Guangxi Medical University,Nanning Guangxi,530021,China;Department of Reproductive Medicine,Hezhou People’s Hospital,Hezhou Guangxi,542800,China;Research Center for Reproductive Medicine,The First Affiliated Hospital of Guangxi Medical University,Nanning Guangxi,530021,China)
出处
《中外女性健康研究》
2026年第1期22-25,共4页
Women's Health Research
基金
广西医疗卫生适宜技术开发与推广应用项目,项目编号:S2019096,课题名称:辅助生殖技术中女性生育力评估与保存的临床应用。
关键词
多囊卵巢综合征
甘油三酯葡萄糖指数
辅助生殖
优质胚胎数
助孕结局
Polycystic Ovary Syndrome
Triglyceride-Glucose Index
Assisted Reproductive Technology
Number of High-Quality Embryos
Assisted Reproductive Outcomes
