摘要
流行性脑脊髓膜炎(流脑)是由脑膜炎奈瑟菌(Nm)感染引起的急性呼吸道传染病,常在冬春季发病和流行,主要表现为脑膜炎和血流感染,两者可同时出现,但多以单一脑膜炎或血流感染为主要表现。根据荚膜多糖的抗原成分可将Nm分为12个血清群,其中A、B、C、W、X和Y为最常见血清群。2025年2月14日兰州大学第二医院报告1例成人流脑疑似病例,根据其流行病学特征、临床表现并结合实验室检测结果,诊断为Y群流脑病例。该病例是甘肃省首例由Y群Nm引起的成人流脑病例,患者继发脑脓肿及菌血症。临床团队通过精准诊断、多模态生命支持及规范重症管理,为患者争取了生存机会,成功避免其出现永久性神经功能缺损。此病例提示需加强Y群流脑的病原学监测与预防,并重视重症病例的早期识别、抗菌药物的精准选择及综合救治。
Epidemic cerebrospinal meningitis(CSM)is an acute respiratory infectious disease caused by Neisseria meningitidis(Nm)infection,often occurring and spreading in winter and spring.It primarily manifests as meningitis and bloodstream infection,which may occur simultaneously,but often presents with either meningitis or bloodstream infection alone as the main symptom.Based on the antigenic components of capsular polysaccharides,Nm can be classified into 12 serotypes,with A,B,C,W,X,and Y being the most common serotypes.On February 14,2025,the Second Hospital of Lanzhou University reported one suspected adult case of epidemic CSM.Based on epidemiological characteristics,clinical manifestations,and laboratory test results,the case was diagnosed with group Y CSM.This case was the first adult case of epidemic CSM caused by group Y Nm in Gansu Province,with secondary brain abscess and bacteremia.The clinical team strived for the survival opportunity for the patient through precise diagnosis,multimodal life support and standardized critical care management,and successfully preventing permanent neurological deficits.This case highlights the need to strengthen pathogen surveillance and prevention of group Y epidemic CSM,with a focus on early identification of severe cases,precise selection of antimicrobial agents,and comprehensive treatment.
作者
杨宝慧
张春霞
张秉玲
张燕菊
YANG Baohui;ZHANG Chunxia;ZHANG Bingling;ZHANG Yanju(Department of Neurosurgery,The Second Hospital of Lanzhou University,Lanzhou 730000,China;Academician and Expert Workstation,The Second Hospital of Lanzhou University,Lanzhou 730000,China;Linxia Prefecture Drug Inspection and Testing Center,Linxia 731100,China;Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,China;Department of Neurocritical Care Medicine,The Second Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《中国感染控制杂志》
北大核心
2026年第1期123-126,共4页
Chinese Journal of Infection Control
关键词
流行性脑脊髓膜炎
Y群脑膜炎奈瑟菌
重症管理
脑脓肿
甘肃省
epidemic cerebrospinal meningitis
group Y Neisseria meningitidis
critical care management
brain abscess
Gansu Province
