摘要
基于脾虚-痰湿作为肥胖发生发展的核心病机,结合现代医学关于免疫炎症在肥胖中发挥关键作用的研究进展,提出“肥胖-脾虚-痰湿-免疫失衡”的多维致病网络;多种健脾理气、化痰祛湿中药可通过改善脾胃运化功能、促进水湿代谢、调节机体免疫稳态等途径治疗肥胖,提示免疫炎症可为阐释“脾虚-痰湿”及“健脾祛湿治肥”提供重要切入点。通过系统剖析“脾虚生湿、痰湿内蕴”与免疫失调在肥胖中的内在关联,旨在为从湿论治肥胖提供理论支持。
Based on spleen deficiency-phlegm dampness as the core pathogenesis of obesity,and integrating recent advances in modern medicine regarding the key role of immune inflammation in obesity,this paper proposes a multidimensional pathogenic network of"obesity-spleen deficiency-phlegm dampness-immune imbalance".Various traditional Chinese medicine(TCM)herbs that strengthen the spleen,regulate qi,and resolve phlegm and dampness can treat obesity by improving spleen-stomach transport and transformation,promoting water-damp metabolism,and regulating immune homeostasis.This highlights immune inflammation as an important entry point to elucidate the TCM concepts of"spleen deficiency-phlegm dampness"and the therapeutic principle of"strengthening the spleen and eliminating dampness to treat obesity".By systematically analyzing the intrinsic connection between"spleen deficiency generating dampness,internal accumulation of phlegm dampness"and immune dysregulation in obesity,this paper aims to provide theoretical support for TCM treatment of obesity based on dampness.
作者
李玉梅
徐鹏
王晓婉
陈树东
杨乐
黄丽华
黎创
何沁池
曾祥曦
王娟娟
毛炜
田瑞敏
LI Yumei;XU Peng;WANG Xiaowan;CHEN Shudong;YANG Le;HUANG Lihua;LI Chuang;HE Qinchi;ZENG Xiangxi;WANG Juanjuan;MAO Wei;TIAN Ruimin(The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou,510120;Guangdong Provincial Academy of Chinese Medical Sciences)
出处
《中医杂志》
北大核心
2026年第1期31-37,共7页
Journal of Traditional Chinese Medicine
基金
广州市科技计划项目(2024A03J0769)
省部共建中医湿证国家重点实验室专项课题(SZ2021ZZ1003)
省部共建中医湿证国家重点实验室开放课题(SZ2022KF16)
广东省中医药局科研项目(20225002,20244023)。
关键词
肥胖
脾虚
痰湿
免疫
炎症
obesity
spleen deficiency
phlegm dampness
immunity
inflammation
