摘要
急性髓系白血病(AML)是一种血液肿瘤,由造血干细胞的异常增殖和成熟受阻引起,导致骨髓和血液中积累大量未成熟或异常的髓细胞。免疫逃逸是导致AML难治和复发的核心机制之一。自然杀伤(NK)细胞在免疫监视和免疫杀伤中起着至关重要的作用。近年来,NK细胞免疫疗法得到了快速发展,尤其是同种异体NK细胞疗法、嵌合抗原受体NK细胞(CAR-NK)疗法、智能化NK细胞疗法,以及NK细胞联合其他治疗手段,为AML复发/难治患者提供了新的治疗希望。中医药对NK细胞功能也具有调节作用,如针灸疗法、中药复方和中药提取物能够提升NK细胞的数量和活性,促进其潜在的抗肿瘤效应。本综述旨在总结NK细胞治疗AML的最新动态,为AML的精准治疗策略提供参考。
Acute myeloid leukemia(AML)is a hematological malignancy caused by abnormal proliferation and blocked maturation of hematopoietic stem cells,leading to the accumulation of a large number of immature or abnormal myeloid cells in the bone marrow and blood.Immune escape is one of the core mechanisms underlying the refractory and relapse of AML.Natural killer(NK)cells play a crucial role in immune surveillance and immune killing.In recent years,NK cell-based immunotherapy has experienced rapid development,especially in allogeneic NK cell therapy,chimeric antigen receptor NK(CAR-NK)cell therapy,intelligent NK cell therapy,and combination strategies with other treatments,providing new therapeutic hope for relapsed and refractory AML patients.Traditional Chinese medicine(TCM)also plays a regulatory role in natural killer(NK)cell function.For instance,acupuncture therapy,Chinese herbal compounds,and herbal extracts can enhance the quantity and activity of NK cells,thereby promoting their potential antitumor effects.This review aims to summarize the latest developments in NK cell therapy for AML and provide scientific references for precise treatment strategies of AML.
作者
陈抒鹏
刘婕
夏凯悦
曾英坚
CHEN Shu-Peng;LIU Jie;XIA Kai-Yue;ZENG Ying-Jian(School of Clinical Medicine,Jiangxi University of Traditional Chinese Medicine;Department of Hematology,The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,Jiangxi Province,China)
出处
《中国实验血液学杂志》
北大核心
2026年第1期288-292,共5页
Journal of Experimental Hematology
基金
国家自然科学基金项目(82260914)
江西省自然科学基金面上项目(20192BAB205100)
江西省中医药管理局中医优势病种培育项目(赣财社指[2022]56号)。
