摘要
目的:分析P物质(SP)、血管活性肠肽(VIP)、5-羟色胺(5-HT)水平与胃食管反流病(GERD)患者睡眠障碍的相关性。方法:回顾性分析2021—2023年该院收治的80例GERD患者的临床资料,纳入观察组,并根据是否发生睡眠障碍将其分为发生患者33例和未发生患者47例。另回顾性分析该院同期80名健康体检者的临床资料,纳入对照组。比较两组SP、VIP、5-HT水平,发生与未发生患者SP、VIP、5-HT水平,采用Pearson相关性分析SP、VIP、5-HT水平与GERD患者睡眠障碍的相关性。结果:观察组VIP、5-HT水平均低于对照组,SP水平高于对照组,差异有统计学意义(P<0.05);发生患者VIP、5-HT水平均低于未发生患者,SP水平高于未发生患者,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,SP水平与GERD患者睡眠障碍呈正相关(r>0,P<0.05),VIP、5-HT水平与GERD患者睡眠障碍均呈负相关(r<0,P<0.05)。结论:SP水平与GERD患者睡眠障碍呈正相关,VIP、5-HT水平与GERD患者睡眠障碍均呈负相关。
Objective:To analyze correlation between substance P(SP),vasoactive intestinal peptide(VIP),5-hydroxytryptamine(5-HT)levels and sleep disorders in patients with gastroesophageal reflux disease(GERD).Methods:The clinical data of 80 patients with GERD admitted to this hospital from 2021 to 2023 were retrospectively analyzed,and they were included in the observation group.According to whether sleep disorders occurred,they were divided into 33 patients with sleep disorders occurrence and 47 patients without sleep disorders occurrence.The clinical data of 80 healthy subjects in the same period were retrospectively analyzed and they were included in the control group.The levels of SP,VIP and 5-HT were compared between the two groups and the patients with and without sleep disorders occurrence.Pearson correlation analysis was used to analyze the correlation between the SP,VIP,5-HT levels and sleep disorders in the GERD patients.Results:The levels of VIP and 5-HT in the observation group were lower than those in the control group,the level of SP was higher than that in the control group,and the differences were statistically significant(P<0.05).The levels of VIP and 5-HT in the patients with occurrence were lower than those in the patients without occurrence,the level of SP was higher than that in the patients without occurrence,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the SP level was positively correlated with sleep disorders in the GERD patients(r>0,P<0.05),and the VIP and 5-HT levels were negatively correlated with sleep disorders in the GERD patients(r<0,P<0.05).Conclusions:The level of SP is positively correlated with sleep disorders in the GERD patients,and the levels of VIP and 5-HT are negatively correlated with sleep disorders in the GERD patients.
作者
田正方
黄宏春
TIAN Zhengfang;HUANG Hongchun(Second Department of Digestive Medicine of the People’s Hospital of Anyang City,Anyang 455000 Henan,China)
出处
《中国民康医学》
2026年第2期136-138,共3页
Medical Journal of Chinese People’s Health
关键词
胃食管反流病
睡眠障碍
P物质
血管活性肠肽
5-羟色胺
相关性
Gastroesophageal reflux disease
Sleep disorders
Substance P
Vasoactive intestinal peptide
5-hydroxytryptamine
Correlation
