摘要
目的:观察通神复脑丸联合奥扎格雷钠治疗后循环缺血发作性头晕患者的效果。方法:选取2023年7月至2024年12月周至县马召中心卫生院收治的86例后循环缺血发作性头晕患者进行前瞻性研究,根据随机数字表法将其分为对照组和观察组各43例。对照组予以奥扎格雷钠治疗,观察组在对照组基础上联合通神复脑丸治疗。比较两组临床疗效,治疗前后血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度、血细胞比容)水平、椎-基底动脉[椎动脉(VA)、基底动脉(BA)]平均血流速度,以及不良反应发生率。结果:观察组治疗总有效率为93.02%(40/43),高于对照组的76.74%(33/43),差异有统计学意义(P<0.05);治疗后,两组全血高切黏度、全血低切黏度、血浆黏度、血细胞比容水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组VA、BA平均血流速度均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:通神复脑丸联合奥扎格雷钠治疗后循环缺血发作性头晕患者可提高治疗总有效率和椎-基底动脉平均血流速度,降低血液流变学指标水平,效果优于单纯奥扎格雷钠治疗。
Objective:To observe effects of Tongshen Funao pills combined with Sodium ozagrel in treatment of patients with posterior circulation ischemia and paroxysmal dizziness.Methods:A prospective study was conducted on 86 patients with posterior circulation ischemia and paroxysmal dizziness admitted to Zhouzhi County Mazhao Health Center from July 2023 to December 2024.According to the random number table method,they were divided into control group and observation group,43 cases in each group.The control group was treated with Sodium ozagrel,while the observation group was treated with Tongshen Funao pills on the basis of that of the control group.The clinical efficacy,the levels of hemorheology indexes(whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,hematocrit),the mean blood flow velocities of basilarvertebral artery[vertebral artery(VA),basilar artery(BA)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.02%(40/43),which was higher than 76.74%(33/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and hematocrit in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the average blood flow velocities of VA and BA in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tongshen Funao pills combined with Sodium ozagrel in the treatment of the patients with posterior circulation ischemia and paroxysmal dizziness can improve the total effective rate of treatment and the average blood flow velocities of basilarvertebral artery,and reduce the levels of hemorheology indexes.Moreover,it is superior to simple Sodium ozagrel treatment.
作者
崔玉倩
杨文静
CUI Yuqian;YANG Wenjing(Department of Neurology of Pucheng County Hospital,Weinan 715500 Shaanxi,China;Department of Pharmacy of Zhouzhi County Mazhao Health Center,Xi’an 710401 Shaanxi,China)
出处
《中国民康医学》
2026年第2期95-97,共3页
Medical Journal of Chinese People’s Health
关键词
后循环缺血
发作性头晕
通神复脑丸
奥扎格雷钠
椎-基底动脉
血液流变学
不良反应
Posterior circulation ischemia
Paroxysmal dizziness
Tongshen Funao pills
Sodium ozagrel
Basilar-vertebral artery
Hemorheology
Adverse reaction
