摘要
目的探究分析对多囊卵巢综合征患者实施抗雄激素药物联合胰岛素增敏剂治疗的效果及对其卵泡发育及排卵率的影响。方法从本院接收的多囊卵巢综合征患者中抽取62例(案例抽取时间2020年12月至2024年12月)进行治疗观察,通过随机数表法进行分组治疗,对照组(n=31例)采取抗雄激素药物治疗,观察组(n=31例)实施抗雄激素药物联合胰岛素增敏剂治疗,比较组间治疗效果、内分泌指标水平[黄体生成素(LH)、睾酮(T)、卵泡刺激素(FSH)]、优势卵泡发生率、排卵率、子宫内膜发育情况及用药产生的不良情况。结果相较于对照组,观察组治疗总有效率更高(P<0.05)。两组内分泌指标水平在治疗前进行比较差异无统计学意义(均P>0.05);治疗后,相关指标均改善,且相较于对照组,观察组的LH、T、FSH均更低(均P<0.05)。观察组的优势卵泡发生率、排卵率高于对照组,子宫内膜发育情况更优(均P<0.05)。相较于对照组,观察组发生不良反应的情况更少,但组间数据比较差异无统计学意义(P>0.05)。结论对多囊卵巢综合征患者实施抗雄激素药物联合胰岛素增敏剂治疗效果显著,可改善患者内分泌指标,促进卵泡发育与子宫内膜发育,提高排卵率,是一种有效的联合用药方式。
Objective To explore and analyze the effects of anti-androgenic drugs combined with insulin sensitizers on patients with polycystic ovary syndrome(PCOS)and their impact on follicular development and ovulation rate.Methods Sixty-two patients with PCOS admitted to our hospital from December 2020 to December 2024 were selected as the observation subjects.They were divided into two groups based on a random number table method and treated with different therapies.The control group(n=31)received antiandrogen therapy,while the observation group(n=31)received antiandrogen therapy combined with insulin sensitizers.The treatment effects,endocrine marker levels[luteinizing hormone(LH),testosterone(T),follicle-stimulating hormone(FSH)],dominant follicle occurrence rate,ovulation rate,endometrial development,and adverse reaction rate were compared between the groups.Results Compared to the control group,the observation group had a higher overall treatment efficacy,with significant differences(P<0.05).The endocrine indicator levels of both groups were compared before treatment(both P<0.05);after treatment,all relevant indicators improved,and LH,T,and FSH levels were lower in the observation group compared to the control group,with significant differences(both P<0.05).The observation group had a higher dominant follicle occurrence rate and ovulation rate,and better endometrial development,with significant differences(both P<0.05).Compared to the control group,the observation group had fewer adverse reactions,but the differences were not significant(P<0.05).Conclusions The combination of anti-androgenic drugs and insulin sensitizers is effective in treating PCOS patients,improving endocrine indicators,promoting follicular and endometrial development,and increasing the ovulation rate.It is an effective combination therapy.
作者
林丽君
LIN Lijun(Department of Obstetrics and Gynecology,Pinghe County Hospital,Zhangzhou City,Zhangzhou,Fujian 363700,China)
出处
《中国医药指南》
2025年第35期9-11,共3页
Guide of China Medicine
基金
福建省自然科学基金联合资金项目(2022J011218)。
关键词
多囊卵巢综合征
抗雄激素药物
胰岛素增敏剂
卵泡发育
排卵率
Polycystic ovary syndrome
Antiandrogen
Insulin sensitizer
Follicular development
Ovulation rate
