摘要
目的 探讨巨细胞病毒(CMV)感染对老年溃疡性结肠炎(UC)患者全身炎症反应及临床转归的影响。方法 采用病例对照研究,分析2020年1月至2024年4月于北京医院就诊的588例老年UC患者病历资料。根据肠道是否存在CMV感染分CMV阳性组(194例)和CMV阴性组(394例)。比较2组老年UC患者的临床特征、C反应蛋白(CRP)、中性粒细胞/淋巴细胞比值(NLR)、全身炎症反应指数(SIRI)水平;记录并比较2组老年UC患者治疗2周后的转归情况。结果 与CMV阴性组相比,CMV阳性组的老年UC患者病程较长,病情更严重,出现发热、腹痛、体重下降占比高,肠镜检查出现纵行溃疡、深大溃疡、凿洞样溃疡占比较高,且CRP、NLR及SIRI水平显著升高,差异均有统计学意义(均P<0.05);CMV阴性组的转归良好率为86.29%(340/394),显著高于CMV阳性组的69.59%(135/194),差异均有统计学意义(均P<0.05)。结论 CMV感染加重老年UC患者的肠道炎症反应程度,不利于临床转归。
Objective To investigate the effect of cytomegalovirus(CMV)infection on systemic inflammatory response and clinical outcome in elderly patients with ulcerative colitis(UC).Methods A case-control study was conducted to analyze the medical records of 588 elderly UC patients who visited Beijing hospitals from January 2020 to April 2024.According to the presence of CMV infection in the intestine,the patients were divided into CMV positive group(194 cases)and CMV negative group(394 cases).The clinical characteristics[clinical symptoms,colonoscopy],hematopoietic index[C-reactive protein(CRP),neutrophil/Lymphocyte ratio(NLR),and systemic inflammatory response index(SIRI)]of the elderly UC patients in the 2 groups were compared.Record and compare the outcomes of two groups of elderly UC patients after two weeks of treatment.Results Compared with the CMV negative group,the CMV positive group had a longer course of disease and more serious disease,with a higher proportion of fever,abdominal pain and body mass loss,and a higher proportion of longitudinal ulcers,deep ulcers and hole-like ulcers in colonoscopy,and the levels of CRP,NLR and SIRI were significantly increased,with statistical significance(P<0.05).The good outcome rate of the CMV-negative group was 86.29%(340/394),significantly higher than that of the CMV-positive group,which was 69.59%(135/194),with statistical significance(P<0.05).Conclusions CMV infection aggravates intestinal inflammation in elderly UC patients,and is not conducive to prognosis.
作者
谢楠
张博
胡丹
XIE Nan;ZHANG Bo;HU Dan(Clinical Laboratory,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;不详)
出处
《中国临床保健杂志》
2025年第6期776-779,共4页
Chinese Journal of Clinical Healthcare
关键词
结肠炎
溃疡性
巨细胞病毒感染
预后
复发
老年人
Colitis,ulcerative
Cytomegalovirus infections
Prognosis
Recurrence
Aged
