摘要
河豚毒素(TTX)是一种强效神经毒素,因具有特异性的钠通道阻断作用而被广泛用于生物医学领域研究。虽然既往研究者已从不同的海洋生物中鉴定出TTX,但TTX的真正来源尚不明确,具体的生物合成途径也不清楚。本文综述了已报道的TTX来源以及TTX的生物合成研究进展,重点关注TTX可能的微生物来源,为TTX的生产与生物合成研究提供科学参考。
Tetrodotoxin(TTX)is a potent neurotoxin known for its specific sodium channel blocking effects,widely used in biomedical research.While TTX has been identified in various marine organisms,its true origin remains unclear,and the specific biosynthetic pathways are yet to be elucidated.The reported sources of TTX and the progress in research on TTX biosynthesis were summarized,with a focus on potential microbial sources of TTX,which could provide scientific reference for the production and biosynthesis studies of TTX.
作者
伍伟
喻惇宁
杨星驰
孙鹏
储智勇
WU Wei;YU Dunning;YANG Xingchi;SUN Peng;CHU Zhiyong(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)
出处
《药学实践与服务》
2026年第1期1-6,共6页
Journal of Pharmaceutical Practice and Service
基金
国家自然科学基金面上项目(82273849)。
