摘要
目的探讨血清血栓素B2(TXB2)联合转化生长因子-β1(TGF-β1)对非瓣膜性房颤(NVAF)患者经导管射频消融术(RFCA)后复发的预测价值。方法回顾性纳入2023年3月至2025年3月于新疆医科大学第四临床医学院首次行RFCA治疗的NVAF患者104例,根据术后3个月内是否复发分为复发组35例和未复发组69例。比较两组一般资料、血生化(包括TXB2、TGF-β1等)和超声指标。多因素logistic回归分析影响因素;受试者操作特征(ROC)曲线计算曲线下面积(AUC)。结果两组年龄、TXB2、TGF-β1、左室射血分数(LVEF)、左心房最大容积(LAVmax)和左心房排空分数(LAEF)比较,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,TXB2(OR=1.456)、TGF-β1(OR=1.987)是术后复发的影响因素。ROC曲线显示,TXB2+TGF-β1预测术后复发的AUC为0.879,灵敏度为87.6%,特异度为76.6%,且两者联合预测的AUC高于TXB2、TGF-β1的AUC(Z=5.032、4.659,P<0.001)。结论TXB2和TGF-β1联合检测能有效评估接受RFCA的NVAF患者的术前风险,并及时予以个体化干预。
Objective To investigate predictive value of serum thromboxane B2(TXB2)combined with transforming growth factor-β1(TGF-β1)for recurrence after radiofrequency catheter ablation(RFCA)in patients with nonvalvular atrial fibrillation(NVAF).Methods A total of 104 NVAF patients underwent RFCA for the first time in the Fourth Clinical Medical College of Xinjiang Medical University from March 2023 to March 2025 were retrospectively included,they were divided into recurrence group(35 cases)and non-recurrence group(69 cases)according to whether they had recurrence within three months after operation.The general datas,blood biochemistry(including TXB2,TGF-β1,etc.)and ultrasound indexes between the two groups were compared.Influencing factors were analyzed by multivariate logistic regression analysis;the area under the curve(AUC)of the receiver operating characteristic(ROC)curve was calculated.Results There were statistically significant differences in age,TXB2,TGF-β1,left ventricular ejection fraction(LVEF),left atrial volume maximum(LAVmax),and left atrial emptying fraction(LAEF)between the two groups(P<0.05).Multivariate logistic regression showed that TXB2(OR=1.456)and TGF-β1(OR=1.987)were the influencing factors of postoperative recurrence.ROC curve showed that AUC of TXB2+TGF-β1 in predicting postoperative recurrence was 0.879,sensitivity was 87.6%and specificity was 76.6%,and was significantly higher than AUC of TXB2 and TGF-β1(Z=5.032,4.659,P<0.001).Conclusion Preoperative detections of TXB2 and TGF-β1 levels have important value in evaluating recurrence risk of NVAF patients after RFCA,the combination of TXB2 and TGF-β1 has better performance.
作者
叶海涛
祖丽皮耶·艾乃斯
杨燕
洪军
刘健
朱敏
YE Haitao;Zulipiye Ainaisi;YANG Yan;HONG Jun;LIU Jian;ZHU Min(The Third Departments of Cardiology,the Fourth Clinical Medical College of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830000,China;Department of Cardiovascular Medicine,Wusu People’s Hospital,Xinjiang Uygur Autonomous Region,Wusu833099,China;Department of Cardiology,Chabuchar County Traditional Chinese Medicine Hospital,Xinjiang Uygur Autonomous Region,Chabuchar835399,China)
出处
《中国医药导报》
2025年第34期87-91,共5页
China Medical Herald
基金
国家中医优势专科建设项目。
关键词
非瓣膜性房颤
经导管射频消融术
复发
血栓素B2
转化生长因子-Β1
Nonvalvular atrial fibrillation
Radiofrequency catheter ablation
Recurrence
Thromboxane B2
Transforming growth factor-β1
