摘要
肾癌是常见的泌尿系统肿瘤。与医学的发展历程类似,肾癌诊断及预后预测技术也经历了从经验医学到精准医学的变化。在经验医学时代,肾癌的诊断及预后预测有赖于临床医师对患者的病理检查结果、影像学图片和血液学报告做出判断。在精准医学时代,以转录组学为代表的组学分析技术和液体活检技术为肾癌的诊断和预后预测提供了新的、有效的方法,研究人员不仅根据分子特征定义了新的肾癌亚型,还构建了大量肾癌预后模型。本文对现有肾癌诊断及预后预测技术的进展与应用进行了总结,旨在为临床医师提供更全面的参考。
Renal cell carcinoma is a common genitourinary cancer.Similar to the development process of medicine,techniques for diagnosis and prognosis prediction of renal cell carcinoma have also experienced the change from empiric medicine to precision medicine.In the era of empiric medicine,the diagnosis and prognosis prediction of renal cell carcinoma relied on clinicians’judgment based on patients’pathologic diagnoses,radiological image,and blood test results.In the era of precision medicine,omics analysis technologies represented by transcriptomics and liquid biopsy technology provided new and effective methods for the diagnosis and prognosis prediction of renal cell carcinoma.Researchers not only defined new subtypes of renal cell carcinoma based on molecular features,but also created numerous renal cell carcinoma prognostic models.This article reviews the progress and application of techniques for diagnosis and prognosis prediction of renal cell carcinoma,hoping to improve clinicians’understanding of this field.
作者
刘子奕
侯乃侨
曹登峰
王逸秋
肖汉卿
郑军华
翟炜
LIU Ziyi;HOU Naiqiao;CAO Dengfeng;WANG Yiqiu;XIAO Hanqing;ZHENG Junhua;ZHAI Wei(Department of Urology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Pathology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)
出处
《海军军医大学学报》
北大核心
2026年第1期112-119,共8页
Academic Journal of Naval Medical University
基金
国家自然科学基金面上项目(82173214).
关键词
肾肿瘤
肾细胞癌
传统技术
组学分析
液体活检
kidney neoplasms
renal cell carcinoma
traditional technology
omics analysis
liquid biopsy
