摘要
近年来,微生理系统(包括类器官与器官芯片)与先进在轨检测技术的结合,正在推动空间生命科学研究范式的根本性变革。系统综述了微生理系统在模拟人体器官三维结构及生理功能方面的优势,并总结了其在国际空间站等平台中的应用实践,涵盖脑、骨、免疫等多个组织模型的研究进展与关键发现。同时,详细评述了高内涵荧光成像、光片显微镜、拉曼光谱和纳米孔测序等原位检测技术的最新发展。进一步分析了当前领域面临的主要挑战,如技术集成度有限、长效培养体系欠缺以及多模态数据融合不足等,并展望了未来智能化、集成化空间实验平台的建设方向,强调通过多模态传感、人工智能与自动化方法的深度融合,推动空间生命科学研究迈向多尺度、系统级和精准解析的新阶段。
In recent years,the integration of microphysiological systems(including organoids and organ-on-a-chip)with advanced in-orbit detection technologies is driving a fundamental transformation in the research paradigm of space life sciences.This paper systematically reviews the advantages of microphysiological systems in mimicking the three-dimensional structure and physiological functions of human organs,and summarizes their application practices on platforms such as the International Space Station,covering research progress and key findings in multiple tissue models,including brain,bone,and immune tissue.It also provides a detailed review of the latest developments in in-situ detection technologies such as high-content fluorescence imaging,light-sheet microscopy,Raman spectroscopy,and nanopore sequencing.Furthermore,it analyzes major current challenges in the field,including limited technology integration,a lack of long-term culture systems,and insufficient multi-modal data fusion.Finally,it looks ahead to the future development direction of intelligent and integrated space experimental platforms,emphasizing that the deep integration of multi-modal sensing,artificial intelligence,and automation methods will propel space life science research into a new stage of multi-scale,systematic,and precise analysis.
作者
王君君
许大钊
张涛
袁永春
王林君
高文婷
闫小军
田清
郑伟波
WANG Jun-jun;XU Da-zhao;ZHANG Tao;YUAN Yong-chun;WANG Lin-jun;GAO Wen-ting;YAN Xiao-jun;TIAN Qing;ZHENG Wei-bo(Shanghai Institute of Technical Physics,Chinese Academy of Sciences,Shanghai 200083,China)
出处
《红外》
2025年第12期23-35,共13页
Infrared
