METTL3在骨关节炎中的研究进展

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摘要甲基化转移酶3(METTL3)作为N6-甲基腺苷(M6A)甲基化中的“编码器”已被证实参与调控各种疾病的发生与发展,尤其是在炎症性疾病中发挥着重要作用。在骨关节炎(OA)的发病过程中,METTL3的表达升高并参与调控破骨细胞的凋亡、滑膜细胞的衰老和炎症以及软骨细胞的功能。本文就M6A甲基化蛋白METTL3在OA患者关节腔内各种细胞中的功能机制研究进行综述,为研究OA发病机制及靶向治疗提供理论依据。

作者罗帅李俊汪盛李小枫栾家杰

机构地区皖南医学院弋矶山医院临床药学科安徽医科大学药学院

出处《医学理论与实践》 2026年第2期225-228,共4页 The Journal of Medical Theory and Practice

基金皖南医学院校中青年科研基金(WK2023ZQNZ28)。

关键词 N6-甲基腺苷甲基化转移酶3 骨关节炎破骨细胞滑膜细胞软骨细胞

分类号 R684.3 [医药卫生—骨科学]

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METTL3在骨关节炎中的研究进展

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