摘要
目的:观察阿尔茨海默病患者中医辨证分型与复合炎症指标的相关性。方法:选符合纳入标准的128例阿尔茨海默病患者作为研究组,并在门诊及体检中心招募60例无认知障碍的个体作为对照组。收集所有研究对象的一般资料,采用简易精神状态评价量表(MMSE)评估认知功能,采集复合炎症指标,包括中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)。进一步分析上述炎症指标与阿尔茨海默病组中医证型(髓海不足证、痰浊蒙窍证、瘀血内阻证)之间的相关性。结果:与对照组比较,阿尔茨海默病组NLR、PLR水平显著高于对照组(P﹤0.05);阿尔茨海默病组痰浊蒙窍证和瘀血内阻证NLR、PLR水平显著高于髓海不足证,痰浊蒙窍证的MLR水平显著高于髓海不足证(P﹤0.05)。结论:阿尔茨海默病患者外周炎症水平升高,且痰浊蒙窍证患者炎症水平更高。
Objective:To approach the correlativity between TCM syndrome types and composite inflammatory indexes of Alzheimer's disease(AD).Methods:128 cases of eligible patients with AD were selected as study group(AD group).In addtion,60 cases of individuals without chief complaint of cognitive impairment were recruited in outpatient and physical examination centers as control group.The general data of all subjects were collected.The cognitive function was evaluated by Mini-Mental State Examination(MMSE).The composite inflammatory indexes were collected,including neutrophil-to-lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)and monocyteto-lymphocyte ratio(MLR).The correlativity between above inflammatory indexes and TCM syndrome types of AD group was further analyzed,such as syndrome of marrow sea insufficiency,syndrome of turbid phlegm confusing orifices,syndrome of internal blockade of static blood.Results:Compared with the control group,the levels of NLR and PLR of AD group were significantly higher than those of control group(P﹤0.05).In AD group,the levels of NLR and PLR of syndrome of turbid phlegm confusing orifices and syndrome of internal blockade of static blood were significantly higher than those of syndrome of marrow sea insufficiency,and MLR level of syndrome of turbid phlegm confusing orifices was significantly higher than that of syndrome of marrow sea insufficiency(P﹤0.05).Conclusion:The level of peripheral inflammation in patients with AD is increased,and the syndrome of turbid phlegm confusing orifices shows a higher level of inflammation.
作者
郭子秋
于顾然
GUO Zi-qiu;YU Gu-ran(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《山西中医》
2026年第1期50-53,共4页
Shanxi Journal of Traditional Chinese Medicine
基金
国家重点研发计划“中医药现代化”重点专项(编号:2022YFC3501403)。
关键词
阿尔茨海默病
中医证型
炎症指标
相关性研究
Alzheimer's disease
TCM syndrome types
inflammatory indexes
study on correlativity
