摘要
BACKGROUND Gastric motility is an essential gastrointestinal function.It can be influenced by age,gender,body composition,and metabolic status.However,published data on these associations remains limited.AIM To assess the relationship between gastric motility and adiposity,and metabolic indicators in a cohort of Sri Lankan office workers.METHODS A cross-sectional study was conducted among 130 office workers(58.5%females)aged 20-50 years(mean 36.81,SD 8.85 years)of the University of Kelaniya,Sri Lanka.Gastric motility was assessed by real-time ultrasonography,using a previously validated method.Fasting antral area(FAA),postprandial antral areas at 1 minutes and 15 minutes(AA1,AA15),and antral contraction frequency(FAC)were measured,and gastric emptying rate(GER)and antral motility index were calculated.Anthropometric parameters were obtained using sensitive scales.Glycated hemoglobin,lipid profile,and liver enzyme levels were measured at an accredited laboratory.RESULTS The mean body mass index(BMI)was 24.36(SD 4.09)kg/m^(2),and 39.2%were overweight or obese.Increased abdominal adiposity was detected in 29.2%and 40.8%had high waist-to-hip ratios.Prediabetes/diabetes were observed in 20.0%,hypercholesterolemia in 47.7%,hypertriglyceridemia in 14.7%,high low-density lipoproteins in 39.2%,and elevated aspartate transaminase and alanine transaminase in 5.4%and 21.5%respectively.FAA had a weak negative correlation with high-density lipoprotein level(r=-0.227,P=0.009),and a positive correlation with waist circumference(r=0.235,P=0.007),and waist-to-hip ratio(r=0.244,P=0.005).GER and AA1 correlated weakly with triglyceride(GER:r=0.174,P=0.048;AA1:r=0.194,P=0.027)and VLDL levels(GER:r=0.183,P=0.038;AA1:r=0.195,P=0.026).In females,AA1 positively correlated with triglycerides(r=0.333,P=0.003),and VLDL levels(r=0.337,P=0.003),and AA15 with BMI(r=0.284,P=0.013)and hip circumference(r=0.229,P=0.047).FAC negatively correlated with BMI(r=-0.234,P=0.042)and hip circumference(r=-0.247,P=0.032).CONCLUSION Gastric motility parameters showed weak associations with metabolic indicators,particularly lipid profiles,and to a lesser extent,with adiposity indicators.The greater number of correlations observed in females suggests the possibility of sex-specific differences in these associations.These findings highlight potential relationships that require confirmation through longitudinal studies.
基金
Supported by the University of Kelaniya,Sri Lanka,Research Grant,No.RP/03/04/03/01/2022.
