摘要
目的:分析黄连荷叶方联合度拉糖肽治疗2型糖尿病(T2DM)(湿热困脾证)肥胖患者疗效及对胰岛素抵抗和内脏脂肪指数的影响。方法:选取2023年1月—2024年12月佛山复星禅诚医院收治的T2DM(湿热困脾证)肥胖患者80例,随机数字表法分为对照组和联合组,每组40例。对照组采用度拉糖肽治疗,联合组加用黄连荷叶方治疗,均治疗12周。比较两组临床疗效,治疗前后血糖指标[餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A_(1)c)、空腹血糖(FPG)]、胰岛素抵抗指数(HOMA-IR)、中医证候积分、肥胖指标、不良反应。结果:联合组疗效高于对照组(P<0.05);治疗后,两组血糖指标、HOMAIR、中医证候积分、肥胖指标均低于治疗前(P<0.05),且联合组FPG、2 h PG、Hb A_(1)c、HOMA-IR、中医证候积分、体脂肪率、内脏脂肪指数均低于对照组(P<0.05,P<0.01);两组不良反应率差异无统计学意义(P>0.05)。结论:T2DM(湿热困脾证)肥胖患者应用黄连荷叶方联合度拉糖肽疗效较好,可降低血糖,改善胰岛素抵抗,改善患者中医证候,降低内脏脂肪指数。
Objective:To analyze the curative effect of Huanglian Heye Formula combined with dulaglutide and its influences on insulin resistance and visceral fat index in patients with obese type 2 diabetes mellitus(T2DM)of damp heat affecting spleen type.Methods:A total of 80 patients with obese T2DM of damp heat affecting spleen type admitted to Foshan Fosun Chancheng Hospital were enrolled between January 2023 and December 2024.According to random number table method,they were divided into control group(dulaglutide)and combination group(Huanglian Heye Formula combined with dulaglutide),40 cases in each group.All patients were treated for 12 weeks.The curative effect,blood glucose indexes[2 h postprandial blood glucose(2hPG),glycated hemoglobin(HbA_(1)c),fasting plasma glucose(FPG)],insulin resistance index(HOMA-IR),scores of TCM syndromes,obesity indexes and adverse reactions in the two groups were compared before and after treatment.Results:The curative effect of combination group was better than that of control group(P<0.05).After treatment,blood glucose indexes,HOMA-IR,scores of TCM syndromes and obesity indexes were decreased in both groups(P<0.05),and FPG,2 hPG,HbA_(1)c,HOMA-IR,scores of TCM syndromes,body fat percentage and visceral fat index in combination group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Curative effect of Huanglian Heye Formula combined with dulaglutide is good in patients with obese T2DM of damp heat affecting spleen type,which can lower blood glucose,improve insulin resistance,TCM syndromes and reduce visceral fat index.
作者
李萌
张淑芬
郭佩湘
LI Meng;ZHANG Shufen;GUO Peixiang(Foshan Fosun Chancheng Hospital,Foshan 528031,China)
出处
《中医药学报》
2026年第1期80-85,共6页
Acta Chinese Medicine and Pharmacology
基金
佛山市自筹经费类科技创新项目(2220001004957)。
关键词
2型糖尿病
湿热困脾证
肥胖
黄连荷叶方
度拉糖肽
Type 2 diabetes mellitus
Damp-heat affecting spleen type
Obesity
Huanglian Heye Formula
Dulaglutide
