摘要
帕金森病(Parkinson disease,PD)是一种慢性神经退行性疾病,其发生机制主要与神经元变性和α突触核蛋白异常聚集有关。研究表明,PD患者合并2型糖尿病的风险较高。降糖药物通过调节糖代谢、改善胰岛素敏感性等途径调控血糖,部分降糖药物还兼具神经保护或抗氧化作用,近年来其在神经退行性疾病中的作用机制研究日益深入。本文对PD的病理基础和相关发病机制进行综述,探讨降糖药物对PD病程进程的影响和作用。
Parkinson disease(PD)is a chronic neurodegenerative disease,and the pathgenesis is mainly related to neuronal degeneration and abnormal accumulation ofαSyn.Some studies have shown that patients with PD are more likely to suffer from type 2 diabetes mellitus.Hypoglycemic drugs regulate blood glucose through modulating glucose metabolism and improving insulin sensitivity.Some of hypoglycemic drugs also have neuroprotective or antioxidant effect,and their mechanisms of action in neurodegenerative diseases have been extensively studied in recent years.This article reviews the pathological basis and related pathogenesis of PD,exploring the effect of hypoglycemic drugs on the progression of PD.
作者
张海涵
荆玮
单悦童
张玉玲
陈安安
龙思琪
王宇泽
李威
潘卫东
ZHANG Haihan;JING Wei;SHAN Yuetong;ZHANG Yuling;CHEN Anan;LONG Siqi;WANG Yuze;LI Weia;PAN Weidong(Department of Neurology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Encephalopathy Research Laboratory,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Encephalopathy I,Anhui Provincial Hospital of Integrated Chinese and Western Medicine the Third Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)
出处
《内科理论与实践》
2025年第5期399-404,共6页
Journal of Internal Medicine Concepts & Practice
基金
上海市浦东新区国家中医药传承发展项目(上海浦东名中医)(No.PDZY-2025-0724)。
关键词
帕金森病
糖尿病
降糖药物
Parkinson disease
Diabetes mellitus
Hypoglycemic agent
