摘要
白蛉作为多种病原体的传播媒介具有重要的流行病学意义,尤其以传播利什曼原虫而广受关注。利什曼原虫的生长发育受到白蛉肠道内多种微生物的影响,同时也会导致白蛉肠道内某些基因差异表达。本文综述了白蛉肠道微生物的组成及其与利什曼原虫的相互作用,以及利什曼原虫导致白蛉肠道功能特征的改变。白蛉、利什曼原虫、微生物群、相关基因的表达之间存在复杂的网络关系,研究其相互作用可为利什曼病的防治与媒介白蛉的控制提供更多策略。
Sandflies,as vectors of multiples pathogens,are of significant epidemiological importance,and has been given attention due to their role in transmitting Leishmania.The growth and development of Leishmania is affected by the diverse microbial communities present in the sandfly gut,which also induces differential gene expression in the sandfly gut.This article summarizes the composition of the sandfly gut microbiota and their interactions with Leishmania,and alterations of functional characteristics in the sandfly gut caused by the parasite.Sandflies,Leishmania,gut microbiota,and gene expression form a complex network,and deciphering their interactions may provide more strategies for leishmaniasis management and sandfly vector control.
作者
何雅琦
崔蕾
方圆
周正斌
张仪
HE Yaqi;CUI Lei;FANG Yuan;ZHOU Zhengbin;ZHANG Yi(National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention/Chinese Center for Tropical Diseases Research/National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases/NHC Key Laboratory on Parasite and Vector Biology/WHO Collaborating Centre for Tropical Diseases/National Center for International Research on Tropical Diseases,Ministry of Science and Technology,Shanghai 200025,China;School of Global Health,Chinese Center for Tropical Diseases Research,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中国寄生虫学与寄生虫病杂志》
北大核心
2025年第5期711-717,共7页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家重点研发计划(2023YFA1801000,2023YFA1801001)。
