摘要
随着社会经济的发展和生育观念的转变,男性生育健康日益受到关注。本文综述了高龄男性对不良妊娠结局的影响及近年来的相关研究成果。现有证据表明,高龄男性可能增加流产、早产、低出生体重儿、巨大儿及出生缺陷等风险,其机制可能与表观遗传变异、基因突变和精子DNA损伤等年龄相关分子学变化密切相关。同时,高龄男性亦可能对辅助生殖技术的结局产生不利影响。总体而言,多数研究支持高龄男性与不良妊娠结局之间存在一定关联,然而相关证据仍不充分,研究结果亦缺乏一致性。未来亟待开展大规模前瞻性研究,以进一步阐明二者关系,并为高龄男性的生育评估和临床决策提供科学依据。
With the development of social economy and the transformation of fertility concepts,male reproductive health is receiving increasing attention..This article reviews the impact of advanced paternal age on adverse pregnancy outcomes and the relevant research achievements in recent years.Existing evidence suggests that advanced paternal age may increase the risk of miscarriage,preterm birth,low birth weight,macrosomia,and birth defects.The mechanisms may be closely related to age-related molecular changes such as epigenetic variations,gene mutations,and DNA fragmentation.At the same time,advanced paternal age may also have adverse effects on the outcomes of assisted reproductive technology.Overall,most studies support the existence of a certain association between advanced paternal age and adverse pregnancy outcomes.However,the relevant evidence is still insufficient,and the research results are also inconsistent.In the future,large-scale prospective studies need to be carried out to further clarify the relationship between the two and provide a scientific basis for the reproductive assessment and clinical decision-making of advanced-aged men.
作者
黎芸菊
赵凯
赵云
LI Yunju;ZHAO Kai;ZHAO Yun(Department of Obstetrics,Hubei Maternal and Child Health Hospital,Huazhong University of Science and Technology,Wuhan,Hubei 430070,China;Reproductive Health Institute,Huazhong University of Science and Technology,Wuhan,Hubei 430070,China)
出处
《中华男科学杂志》
2025年第12期1119-1124,共6页
National Journal of Andrology
基金
湖北省“楚天英才计划”医疗卫生人才项目(鄂卫通[2023]27号)。
关键词
高龄男性
辅助生殖技术
不良妊娠结局
表观遗传学
advanced-aged men
assisted reproductive technology
adverse pregnancy outcomes
epigenetics
