摘要
Biomaterials serve as bridges between synthetic structures and biological systems,facilitating interactions with bodily tissues and regulating cellular responses.However,the intricate mechanisms governing cell-material interactions within the body are not fully understood.To address these challenges,single-cell transcriptomics and spatial technologies have emerged as promising tools.This review introduces the concept of the‘Biomaterial-mediated Cell Atlas’and summarizes its recent advances in biomaterials research.Building upon the framework of the Human Cell Atlas,it can extend its scope to include biomaterial-mediated cellular responses.The prin-ciples and workflows of single-cell and spatial transcriptomics are then presented,emphasizing their potential to reveal cellular diversity and spatial arrangements affecting material-cell interactions.Furthermore,transcriptomics-driven approaches are highlighted for their potential in mapping biomaterial-cell communica-tion pathways,which are essential for elucidating biological mechanisms and guiding material design.Chal-lenges inherent to current methodologies and emerging frontiers in this interdisciplinary field are discussed.
基金
supported by the National Natural Science Foun-dation of China(Grant No.82301134)
Guangdong Basic and Applied Basic Research Foundation(grant numbers 2022A1515111092,and 2022A1515110379).
