摘要
昼夜节律(CR)是生物体内的一种内在生物钟机制,通过调节生理和生化过程,使生物体能够与外部环境的周期性波动保持同步。这种节律性不仅影响睡眠-觉醒周期,还涉及代谢、激素分泌、细胞增殖和免疫反应等多种生理功能。年龄相关性黄斑变性(ARMD)作为一种常见的视网膜疾病,已被发现与CR的失调存在显著关联。ARMD是导致老年人视力丧失的主要原因之一,其发病机制复杂,涉及遗传、环境和生活方式等多种因素。文章重点探讨CR与ARMD之间的分子机制,分析CR紊乱如何通过影响视网膜细胞的生理状态和代谢过程,进而导致ARMD的发生和发展。同时,文章阐述CR与氧化应激、调控Aβ、炎症通路及线粒体稳态之间对ARMD的交互作用,通过深入探讨CR与ARMD之间的关系,希望为未来的临床干预和治疗提供新的思路和方向。
Circadian rhythm(CR)is an intrinsic biological clock mechanism within organisms that regulates physiological and biochemical processes,enabling synchronization with periodic fluctuations in the external environment.This rhythmicity not only influences the sleep-wake cycle but also encompasses various physiological functions,including metabolism,hormone secretion,cell proliferation,and immune responses.Age-related macular degeneration(ARMD),a prevalent retinal disease,has been significantly associated with disruptions in CR.ARMD is among the leading causes of vision loss in the elderly,with a complex pathogenesis involving multiple factors such as genetics,environmental influences,and lifestyle choices.This article will focus on the molecular mechanisms linking CR and ARMD,analyzing how disruptions in CR affect the physiological state and metabolic processes of retinal cells,ultimately contributing to the onset and progression of ARMD.Additionally,this article will elucidate the interactions effects of CR on ARMD in relation to oxidative stress,regulation of Aβ,inflammatory pathways,and mitochondrial homeostasis.By deepening our understanding of the relationship between CR and ARMD,we aim to provide new insights and directions for future clinical interventions and treatments.
作者
吴紫阳
邹文军
Wu Ziyang;Zou Wenjun(Jiangnan University Medical Center,Wuxi No.2 People's Hospital,Wuxi 214000,Jiangsu Province,China;Wuxi School of Medicine,Jiangnan University,Wuxi 214122,Jiangsu Province,China)
出处
《国际眼科杂志》
2026年第1期50-55,共6页
International Eye Science
基金
无锡市“双百”中青年医疗卫生拔尖人才项目(No.BJ2023036)。
关键词
昼夜节律
年龄相关性黄斑变性
感光细胞
视网膜
circadian rhythms
age-related macular degeneration
photoreceptor cells
retina
