摘要
N-methyl-D-aspartate receptors(NMDARs)andα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs)mediate the majority of excitatory synaptic transmission in central nervous system.Dysfunction of these receptors may result in various diseases,including epilepsy.In recent years,a growing number of studies have targeted NMDARs and AMPARs to screen for antiepileptic agents that are both efficacious and well-tolerated.This review summarizes compounds,herbal extracts,and herbal complexes of traditional Chinese medicine(TCM)that have demonstrated antiepileptic effects through their modulation of NMDARs and AMPARs over the past 25 years.Furthermore,this review also systematically synthesizes the molecular mechanisms underlying these drugs,with the aim of facilitating the rational design and translational development of future antiepileptic therapeutic agents.
基金
supported by the National Key R&D Program of China 2022YFC3500501,National Science Foundation of China(NSFC,82471479 to W.Z.,82474103 and 82174004 to D.K.)
the National Science Foundation of Hebei Province(H2022206211 to W.Z.)
Science and Technology Research Project ofHebei Colleges(BJK2023072 to Z.Y.)
Spring Rain Programof HebeiMedical University(CYYQ2023003 to Z.Y.)
Graduate Innovation Funding Project of Degree Office of Hebei Provincial Department of Education for Higher Education Institutions(CXZZBS2024121 to S.C.)
Key laboratory of Neural and Vascular Biology,Ministry of Education of China(NV20230002)。
