摘要
Aging and metabolic diseases are intricately linked through bidirectional molecular mechanisms that foster a harmful cycle of physiological decline.This cycle is driven by several key factors,including altered nutrient sensing,mitochondrial dysfunction,cellular senescence,chronic inflammation,epigenetic modifications,circadian rhythm disruptions,and imbalances in the gut microbiota.Emerging interventions targeting this aging-metabolism axis hold significant promise for extending healthspan.These approaches include the use of pharmacological mimetics,senolytics,multi-omics strategies,and microbiome modulation,all of which aim to restore metabolic homeostasis and mitigate age-related pathologies.However,several challenges remain in translating these strategies into clinical practice.These include the need for tissue-specific targeting,ensuring the long-term safety of interventions,and addressing socioeconomic disparities in healthcare access.Future research efforts are focusing on integrating multi-omic technologies,organoid and human cellular models,and developing equitable precision medicine frameworks.These initiatives aim to extend healthspan and reduce the global impact of aging-related metabolic diseases.
基金
supported by the National Natural Science Foundation of China(Grant No.82470744)
Jiangsu Research Innovation Program for College Graduates(No.KYCX25_3257)
Qinglan Project of Jiangsu Province Higher Education,National Key Research and Development Program of China(2023YFF1205103-2)
National Natural Science Foundation of China(32170756)
Beijing Life Science Academy(2024300CD0050).
