摘要
Actively identifying the risk factors and predictive indicators associated with portal vein thrombosis(PVT)in liver cirrhosis(LC)can enable early diagnosis and treatment,which is of great significance for prolonging the survival of patients with LC.Hemodynamic disturbances,advanced LC,vascular endothelial injury,and mutations in thrombophilic genetic factors are established risk factors for PVT-LC.Venous dilatation and decreased blood flow velocity contribute to hemodynamic disturbances.The severity of LC can be assessed by the degree of portal hypertension,liver metabolic function biomarkers,and validated liver scoring systems.Iatrogenic interventions,endotoxemia,and metabolic syndrome may induce vascular endothelial injury and hypercoagulability,the latter of which can be quantified via coagulation-anticoagulation-fibrinolysis biomarkers.Mutations in thrombophilic genetic factors,such as Factor V Leiden,MTHFR C667T,and JAK2 V617F,disrupt coagulation-anticoagulation homeostasis and predispose patients to PVT-LC.This review specifically focuses on comprehensively delineating established risk factors and predictive indicators for PVT-LC,thereby providing a theoretical foundation for the construction of clinically applicable PVT predictive models to guide early interventions and improve the prognosis.Future research should further validate the associations between recently proposed risk factors and PVT-LC,while simultaneously establishing cutoff values for indicators with robust predictive value to construct a clinically applicable PVT prediction framework.
基金
the General Program of the Chongqing Natural Science Foundation(CSTB2022NSCQ-MSX0909 to HZ)
the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University(No.2021240308 to HZ)
the Group Medical Aid Project for the Tibet Autonomous Region,supported by the Natural Science Foundation of the Tibet Autonomous Region(XZ2023ZR-ZY75(Z)).
