支气管镜肺泡灌洗及氨溴索联合治疗对重症肺炎患者血清炎性因子水平及氧合指标的影响

Impact of Bronchoalveolar Lavage Combined with Ambroxol Therapy on the Levels of Serum Inflammatory Factors and Oxygenation Parameters in Patients with Severe Pneumonia

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摘要目的分析支气管镜肺泡灌洗及氨溴索联合治疗对重症肺炎患者血清炎性因子水平及氧合指标的影响。方法选取2022年1月至2024年12月我院收治的重症肺炎患者100例,按随机数字表法分为两组各50例。对照组予以氨溴索治疗,观察组在对照组基础上采用支气管镜肺泡灌洗治疗。对比两组的临床疗效、血清炎性因子水平、氧合指标及不良反应发生情况。结果观察组的总有效率为94.00%,高于对照组的80.00%(P<0.05)。治疗后,观察组的CRP、WBC、PCT水平低于对照组,PaO_(2)、PaO_(2)/FiO_(2)高于对照组(P<0.05)。两组的不良反应发生率相比,差异无统计学意义(P>0.05)。结论针对重症肺炎患者,采用支气管镜肺泡灌洗与氨溴索联合治疗的效果更佳,能降低血清炎性因子水平,改善氧合功能,且未增加不良反应风险。 Objective To analyze the impact of bronchoalveolar lavage combined with ambroxol therapy on the levels of serum inflammatory factors and oxygenation parameters in patients with severe pneumonia.Methods A total of 100 patients with severe pneumonia admitted to our hospital from January 2022 to December 2024 were selected and divided into two groups using a random number table method.The control group was treated with ambroxol,while the observation group was treated with bronchoalveolar lavage on the basis of the control group.The clinical efficacy,levels of serum inflammatory factors,oxygenation parameters,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.00%,higher than 80.00%of the control group(P<0.05).After treatment,the CRP,WBC and PCT levels of the observation group were lower than those of the control group,and the PaO_(2) and PaO_(2)/FiO_(2) were higher than those of the control group(P<0.05).No statistically significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions For patients with severe pneumonia,bronchoalveolar lavage combined with ambroxol has better treatment effect,can reduce the levels of serum inflammatory factors,improve the oxygenation function,and does not increase the risk of adverse reactions.

作者谢玉芳黄小燕杨凤刘泉华胡燕霞 XIE Yufang;HUANG Xiaoyan;YANG Feng;LIU Quanhua;HU Yanxia(Respiratory Diagnosis and Treatment Center,Jiujiang First People's Hospital,Jiujiang 332000,China)

机构地区九江市第一人民医院呼吸诊疗中心

出处《临床医学工程》 2025年第12期1415-1418,共4页 Clinical Medicine & Engineering

关键词重症肺炎支气管镜肺泡灌洗氨溴索炎性因子氧合指标 Severe pneumonia Bronchoalveolar lavage Ambroxol Inflammatory factor Oxygenation parameter

分类号 R563.1 [医药卫生—呼吸系统]