摘要
本文系统综述了蒙药经典名方文冠木-4味汤(森登-4味汤)的研究进展,重点梳理了其古籍源流、单味药化学成分与药理作用,以及复方在抗炎、抗氧化及治疗风湿性疾病方面的现代研究证据,并详细比较了不同古籍中两种文冠木-4味汤的组成与功效差异,总结了各单味药(文冠木、诃子、秦艽、黄柏)及其活性成分(如没食子酸、龙胆苦苷、小檗碱等)在关节炎模型中的药理机制。该方剂临床疗效明确,其系统性研究仍较薄弱,未来应结合多学科技术手段,深入阐明其物质基础与作用机制,以推动蒙医药的现代化与创新研发。
This review systematically summarizes the research progress on the classic Mongolian medicine formula Wenguanmu-4 Decoction(Sendeng-4 Decoction).It focuses on its historical origins and documentation in ancient texts,the chemical composition and pharmacological activities of its individual constituent herbs,as well as modern evidence supporting the anti-inflammatory,antioxidant,and anti-rheumatic effects of the compound formulation.The article provides a detailed comparison of the composition and therapeutic differences between the two variants of Wenguanmu-4 Decoction recorded in various classical texts.Furthermore,it summarizes the pharmacological mechanisms of the constituent herbs-Xanthoceras sorbifolia,Terminalia chebula,Gentiana macrophylla,and Phellodendron chinense-and their active compounds(such as gallic acid,gentiopicroside,and berberine)in arthritis models.Despite the well-documented clinical efficacy of this formula,systematic research remains limited.Future studies should integrate multidisciplinary approaches to further elucidate its material basis and mechanisms of action,thereby advancing the modernization and innovative development of Mongolian medicine.
作者
黄格尔柱拉
拉喜那木吉拉
敖敦格日乐
Huanggeerzhula;Laxinamujila;Aodungerile(Mongolian Medical College,Inner Mongolia Minzu University,Tongliao 028000,China)
出处
《中国处方药》
2025年第24期115-120,共6页
Journal of China Prescription Drug
基金
内蒙古自治区教育厅中(蒙)药资源开发利用集成攻关大平台项目(KYPT23004)
国家中医药管理局高水平中医药重点学科建设项目(ZYYZOKK-2023028)
一流学科科研专项项目(YLXKZX-NMD-002)
内蒙古自治区自然科学基金项目(2025QN08019)。
关键词
文冠木-4味汤
古籍记载
药理作用
Wenguanmu-4 Decoction
Ancient records
Pharmacological action
