摘要
目的 分析1990—2021年中国新生儿黄疸(NNJ)疾病负担水平及变化趋势。方法 收集2021年全球疾病负担研究数据库中1990—2021年中国NNJ疾病负担的相关数据,采用患病率、死亡率、伤残调整寿命年(DALY)率等指标进行描述性分析,使用Joinpoint软件计算患病率、死亡率及DALY率的平均年度变化百分比(AAPC)来评估疾病的时间变化趋势。结果 2021年中国NNJ的患病率、死亡率、DALY率分别为60.17人/10万、42.06人/10万、3 804.15/10万人年。1990—2021年中国NNJ患病率、死亡率、DALY率均呈下降趋势,AAPC分别为[-1.57%,95%CI(-1.62%,-1.53%)]、[-7.01%,95%CI(-7.26%,-6.77%)]、[-7.00%,95%CI(-7.24%,-6.76%)]。2021年,在性别方面,男性患儿NNJ患病率、死亡率和DALY率均高于女性患儿;在年龄方面,日龄0~6 d的患儿死亡率、DALY率均高于日龄7~27 d的患儿,但患病率无明显差异。NNJ疾病负担存在显著的地区不平等,低社会人口学指数地区负担最重且改善最慢,而中国处于中等水平。结论中国NNJ的患病率、死亡率、DALY率均呈下降趋势,男性新生儿疾病负担高于女性新生儿,0~6 d的新生儿疾病负担高于7~27 d新生儿。
Objective This study analyzed the burden and changing trends of neonatal jaundice(NNJ)in China from 1990 to 2021.Methods Data on the burden of NNJ in China from 1990 to 2021 were collected from the 2021 Global Burden of Disease Study database.Descriptive analysis was performed using indicators such as prevalence,mortality rate,and disability-adjusted life years(DALY)rate.Joinpoint software was used to calculate the average annual percentage change(AAPC)and 95%confidence interval(CI)of the prevalence,mortality rate,and DALY rate,to analyze the temporal trends.Results In 2021,the prevalence,mortality rate,and DALY rate of NNJ in China were 60.17 per 100,000 people,42.06 per 100,000 people,and 3,804.15 per 100,000 person-years.From 1990 to 2021,the prevalence,mortality rate,and DALY rate of NNJ in China all showed a downward trend,with AAPCs of[-1.57%,95%CI(-1.62%,-1.53%)],[-7.01%,95%CI(-7.26%,-6.77%)],and[-7.00%,95%CI(-7.24%,-6.76%)],respectively.In 2021,male infants had higher NNJ prevalence,mortality rate,and DALY rate than female infants;in terms of age,infants aged 0~6 days had higher mortality and DALY rates than infants aged 7~27 days,but there was no significant difference in prevalence.There were significant global inequalities in the burden of NNJ across regions with different Socio-demographic Index(SDI)levels.Low-SDI regions bear the heaviest burden and show the slowest improvement,while China is at an intermediate level.Conclusion The prevalence,mortality rate,and DALY rate of NNJ in China showed a downward trend.The disease burden was higher in male infants than in female infants,and higher in newborns aged 0~6 days than in newborns aged 7~27 days.
作者
李佳丽
马友
黄子睿
程雁
LI Jiali;MA You;HUANG Zirui;CHENG Yan(Department of Pediatrics,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China;Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)
出处
《医学新知》
2025年第12期1430-1437,共8页
New Medicine
基金
安徽医科大学学科建设项目(9101128801)。
