摘要
目的:了解中医古籍中抗疲劳方剂的用药特点及其规律。方法:以《中华医典》(第5版)为数据来源,以“疲劳”“乏力”“倦怠”“虚劳”等关键词检索相关方剂,筛选符合标准的处方。运用古今医案云平台V3.0进行数据挖掘,对药物频次、性味归经进行描述性统计,采用关联规则、层次聚类方法及复杂网络分析核心处方。结果:共纳入2137首抗疲劳方剂,出现频次排名前5位的方剂依次为补中益气汤、四物汤、十全大补汤、六君子汤、四君子汤;高频药物包括炙甘草、人参、当归、白术、茯苓等;药性以温性占比最高;药味以甘味占比最高;归经涉及12经,其中脾、肺、心、肾、肝、胃经出现6000次以上。关联规则分析得到12对核心药对和8组关键角药,出现频次最高的药对为人参-炙甘草,角药为白术-炙甘草-人参;层次聚类分析将核心药物分为4类;复杂网络分析确定了一个由5味药物构成的核心处方。结论:中医古籍抗疲劳方剂以补虚为核心,重在健脾益气、多脏同调、气血并治,药性以甘温为主。核心药对与处方揭示了稳定的益气配伍结构。研究从文献角度系统印证了“形不足者,温之以气”的治疗思想,为现代临床辨治疲劳相关状态提供了经典方药规律参考。
Objective:To explore the characteristics and patterns of anti-fatigue formulae in traditional Chinese medical classics.Methods:Using Chinese Medical Classics(Fifth Edition)as the data source,relevant formulas were retrieved using keywords such as"fatigue,""asthenia,""listless"and"consumptive fatigue,"followed by screening to select prescriptions that met the criteria.Utilizing the Ancient and Modern Medical Case Cloud Platform V3.0 for data mining,descriptive statistics were performed on medication frequency,property,flavor and meridian tropism.Association rules,hierarchical clustering,and complex network analysis were employed to identify core prescriptions.Results:A total of 2137 anti-fatigue formulas were included.The top five most frequently used formulas were Buzhong Yiqi decoction,Siwu decoction,Shiquan Dabu decoction,Liujunzi decoction,and Sijunzi decoction.High-frequency herbs included Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Ginseng Radix et Rhizoma,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma,Poria,etc.For the properties,warm-natured herbs accounted for the highest proportion.For the flavors,sweet-flavored herbs accounted for the highest proportion.The meridian tropism covered all 12 meridians,with the spleen,lung,heart,kidney,liver,and stomach meridians each appearing over 6000 times.The association rule analysis yielded 12 core herb pairs and 8 key three-herb formulas.The most frequently occurring herb pair was Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,and the most frequently occurring three-herb formulas was Atractylodis Macrocephalae Rhizoma-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle-Ginseng Radix et Rhizoma.Hierarchical cluster analysis grouped the core herbs into 4 clusters.Complex network analysis identified a core prescription consisting of 5 herbs.Conclusion:Anti-fatigue formulas from traditional Chinese medical classics are centered on tonifying deficiency,with an emphasis on spleen fortification and qi supplementation,multi-organ regulation,and simultaneous treatment of qi and blood.The medicinal properties are primarily sweet and warm.The core herb pairs and prescriptions reveal a stable structure of qi-tonifying compatibility.The study systematically corroborates,from a literature perspective,the therapeutic principle that"for physical deficiency,warm it with qi-tonifying methods."It provides a reference to patterns of classical formulas and herbs for the modern clinical differentiation and treatment of fatigue-related conditions.
作者
何成诚
王强
赵为民
吴今普
李雪园
杨薇
HE Cheng-cheng;WANG Qiang;ZHAO Wei-min;WU Jin-pu;LI Xue-yuan;YANG Wei(Changchun University of Chinese Medicine,Changchun 130117,China;Changchun Hospital of TCM,Changchun 130022,China;Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China)
出处
《中国合理用药探索》
2025年第12期154-160,共7页
Chinese Journal of Rational Drug Use
基金
吉林省中医药管理局科技项目(2024213)。
关键词
疲劳
中医古籍
数据挖掘
中药方剂
用药规律
fatigue
traditional Chinese medical classics
data mining
traditional Chinese medicine formulas
medication patterns
