摘要
目的:探讨通淋固本汤加减联合盐酸坦索罗辛在体外冲击波碎石术(extracorporeal shock wave lithotripsy,ESWL)后直径<2cm上尿路结石患者中的应用效果。方法:回顾性纳入我院2022年6月至2023年8月期间收治的30例ESWL后接受通淋固本汤加减联合盐酸坦索罗辛治疗上尿路结石患者为研究组,采用1:1配对原则纳入同期30例ESWL后接受盐酸坦索罗辛治疗上尿路结石患者为对照1组,同期30例ESWL接受通淋固本汤加减治疗上尿路结石患者为对照2组。对比三组临床疗效、腹痛减轻时间、血尿消失时间、结石排出时间、肾功能指标[血肌酐(serum creatinine,SCr)、尿酸(uric acid,UA)、中性粒细胞明胶酶相关脂蛋白(neutrophil gelatinase-associated lipoprotein,NGAL)]和炎症介质指标[白细胞介素-1β(interleukin-1β,IL-1β)、白细胞计数(white blood cell count,WBC)、单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)、白细胞介素-8(interleukin-8,IL-8)]和不良反应发生率。结果:研究组的临床总有效率高于对照1组、对照2组(P<0.05)。研究组的腹痛减轻时间、血尿消失时间、结石排出时间短于对照1组、对照2组(P<0.05)。研究组治疗后SCr、UA、NGAL、IL-1B、WBC、MCP-1、IL-8水平低于对照1组、对照2组(P<0.05)。三组不良反应发生率组间对比未见统计学差异(P>0.05)。结论:通淋固本汤加减联合盐酸坦索罗辛治疗ESWL后直径<2cm上尿路结石患者,可提高临床总有效率,降低炎症因子水平,减轻肾功能损伤,安全有效。
Objective:To investigate the application effect of modified Tonglin Guben Decoction combined with tamsulosin hydrochloride in patients with upper urinary tract stones<2 cm in diameter after extracorporeal shock wave lithotripsy(ESWL).Method:A total of 30 patients with upper urinary tract stones treated with modified Tonglin Guben Decoction combined with tamlosin hydrochloride after ESWL in our hospital from June 2022 to August 2023 were retrospectively included as the study group,30 patients with upper urinary tract stones treated with tamsulosin hydrochloride after ESWL during the same period were included as control group 1,and 30 patients with upper urinary tract stones treated with modified Tonglin Guben Decoction after ESWL during the same period as control group 2 by the principle of 1:1 paired.The clinical efficacy,time for abdominal pain relief,time for hematuria to disappear,time for stone expulsion,renal function indicators[serum creatinine(SCr),uric acid(UA),neutrophil gelatinase-associated lipoprotein(NGAL)]and flammatory mediator indicators[interleukin-1β(IL-1β),white blood cell count(WBC),monocyte chemoattractor protein-1(MCP-1),interleukin-8(IL-8)]and the occurrence of adverse reactions of the three groups were compared.Result:The total clinical effective rate of the study group was higher than that of control group 1 and control group 2(P<0.05).The time for abdominal pain relief,time for hematuria to disappear and time for stone expulsion of the study group was shorter than those of control group 1 and control group 2(P<0.05).The levels of SCr,UA,NGAL,IL-1β,WBC,MCP-1 and IL-8 of the study group after treatment were lower than those of control group 1 and control group 2(p<0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Modified Tonglin Guben Decoction combined with tamlosin hydrochloride in patients with upper urinary tract stones<2 cm in diameter after ESWL,can increase the total clinical effective rate,reduce the inflammatory factors levels,reduce renal function damage,and is safe and effective.
作者
张旺龙
曹祥茂
阴伟林
肖松子
ZHANG Wang-long;CAO Xiang-mao;YIN Wei-lin;XIAO Song-zi(Department of Urology Surgery,Ninghua County General Hospital of Sanming,Sanming,Fujian,365400,China)
出处
《现代生物医学进展》
2025年第22期3581-3589,共9页
Progress in Modern Biomedicine
基金
三明市卫生健康青年科研课题(2023-S-71)。
关键词
通淋固本汤
盐酸坦索罗辛
体外冲击波碎石术
上尿路结石
临床疗效
Tonglin Guben Decoction
Tamlosin hydrochloride
Extracorporeal shock wave lithotripsy
Upper urinary tract stones
Clinical efficacy
