摘要
深部脑结构的功能调控在精神疾病治疗中具有重要意义,但目前主要依赖侵入性技术实现,如深部脑刺激等。时间干涉(temporal interference,TI)经颅电刺激是一种新兴的非侵入性神经调控技术,能够精准地调节大脑深部核团的活动,为精神疾病的治疗提供了一种创新且有前景的手段。近年来,关于健康个体和神经疾病(如帕金森病)患者的相关研究为时间干涉的深部脑调控能力提供了初步支持。同时,多项临床注册研究显示,研究者正在积极探索时间干涉在精神疾病治疗中的应用潜力。本文系统综述了时间干涉的基本原理、调控机制及其在精神疾病治疗中的研究进展,并深入分析当前亟待解决的关键科学问题,以期为该领域的基础研究和临床转化提供有价值的参考。
The functional modulation of deep brain structures plays a crucial role in the treatment of psychiatric disorders;however,current approaches primarily rely on invasive techniques such as deep brain stimulation.Temporal Interference(TI)transcranial electrical stimulation is an emerging non-invasive neuromodulation technique capable of precisely regulating the activity of deep brain nuclei,offering an innovative and promising approach for psychiatric disorder treatment.In recent years,studies conducted on healthy individuals and patients with neurological disorders(e.g.,Parkinson's disease)have provided preliminary evidence supporting the deep brain modulation capabilities of TI.Meanwhile,multiple registered clinical studies are actively investigating its potential applications in psychiatric treatment.This review systematically summarizes the fundamental principles,neuromodulatory mechanisms,and recent research advances of TI in psychiatric disorders.Additionally,it highlights key scientific issues that need to be addressed to facilitate further basic research and clinical translation in this field.
作者
张咏熹
刘珂
臧振享
王鹏飞
王刚
杨志
Zhang Yongxi;Liu Ke;Zang Zhenxiang;Wang Pengfei;Wang Gang;Yang Zhi(Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders,National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)
出处
《中华精神科杂志》
北大核心
2025年第12期883-890,共8页
Chinese Journal of Psychiatry
基金
国家自然科学基金面上项目(82471576)。
关键词
电刺激
时间干涉刺激
精神疾病治疗
非侵入性脑调控
深部脑调控
神经调控
Electric stimulation
Temporal interference stimulation
Psychiatric disorder treatment
Non-invasive brain modulation
Deep brain modulation
Neuromodulation
