摘要
目的分析原发性高血压患者光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)参数的变化,探讨血压对OCTA参数的影响。方法选择164例原发性高血压患者,根据血压控制与否分为血压控制组(n=92)和血压非控制组(n=72)。对所有患者视盘及黄斑行OCTA检查,选择右眼分析。结果两组患者视网膜神经纤维层(RNFL)厚度、放射状视盘周围毛细血管(RPC)总血管密度、RPC总小血管密度、近中心凹浅层血管(SCP)密度、近中心凹深层血管(DCP)密度差异均无统计学意义。两组患者中心凹无血管区(FAZ)面积、FAZ直径、中心凹视网膜厚度差异均无统计学意义。血压未控制组旁中心凹SCP密度、旁中心凹DCP密度、血管分形维数(FD)明显低于血压控制组(P<0.05)。多重线性回归分析显示血压升高是旁中心凹DCP密度减低的独立相关因素(P=0.026),不影响旁中心凹SCP密度、血管FD水平。结论高血压患者血压水平影响旁中心凹DCP密度,与其他OCTA参数无明显相关性。
Objective To analyze the changes in optical coherence tomography angiography(OCTA)parameters in patients with essential hypertension,and to explore the effect of blood pressure on OCTA parameters.Methods A total of 164 patients with essential hypertension were selected and divided into controlled blood pressure group(n=92)and uncontrolled blood pressure group(n=72).OCTA examination was performed on the optic disc and macula of all patients,and the right eyes were selected for analysis.Results There were no significant differences in retinal nerve fiber layer(RNFL)thickness,radial peripapillary capillary(RPC)total vascular density,RPC total small vessel density,perifovea superficial capillary plexus(SCP)vascular density,and perifovea deep capillary plexus(DCP)vascular density between the two groups of patients.There were no significant differences in foveal avascular zone(FAZ)area,FAZ diameter,and fovea retinal thickness between the two groups of patients.The density of the parafovea SCP,parafovea DCP,and fractal dimension(FD)in the uncontrolled blood pressure group were significantly lower than those in the controlled blood pressure group(P<0.05).Multiple linear regression analysis showed that elevation of blood pressure was a independently related factor of reduced parafovea DCP density(P=0.026),while there was no correlation between the uncontrolled blood pressure and parafovea SCP density and FD level.Conclusions The blood pressure level is correlated with the parafovea DCP density,while has no correlation with other OCTA parameters in hypertension patients.
作者
马金宝
曹凯
王国宏
秦明照
江雪
郭彩霞
何玉
张永鹏
刘琦
MA Jinbao;CAO Kai;WANG Guohong;QIN Mingzhao;JIANG Xue;GUO Caixia;HE Yu;ZHANG Yongpeng;LIU Qi(Department of Geriatrics,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Beijing Institute of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Cardiovascular Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)
出处
《中国临床医学》
2025年第6期967-972,共6页
Chinese Journal of Clinical Medicine
基金
首都卫生发展科研专项(2024-1-2051)。
关键词
原发性高血压
光学相干断层扫描血管成像
视盘
黄斑
血管密度
essential hypertension
optical coherence tomography angiography
optic disc
macula
vessel density
