摘要
软骨在人体中发挥多种重要作用,但由于其组织结构的特殊性,自我修复能力弱。力学信号可以作用于软骨细胞调节软骨组织的稳态和疾病的发生发展。机械负荷既可以促进软骨细胞的生长发育维持关节稳定,也可能破坏软骨细胞损害关节健康。力学信号对软骨细胞有重要作用,但软骨细胞接受力学负荷的传感器及其机制尚不清楚。本文综述了软骨细胞上的力学传感器接受生理范围内机械刺激和异常机械刺激时对软骨细胞代谢及生命活动的影响。
Cartilage plays a multitude of crucial roles in the human body,yet due to the peculiarities of its tissue structure,it possesses a weak capacity for self-repair.Mechanical signals can act upon chondrocytes to regulate the homeostasis of cartilage tissue and the onset and progression of diseases.Mechanical loading can both promote the growth and development of chondrocytes to maintain joint stability,and potentially damage chondrocytes and impair joint health.Mechanical signals play a significant role in chondrocytes.However,the receptors by which chondrocytes perceive mechanical loads and their mechanisms remain unclear.This article reviews the impact of physiological and abnormal mechanical stimuli on the metabolism and vital activities of chondrocytes through mechanoreceptors on chondrocytes.
作者
杨梓桐
房兵
YANG Zitong;FANG Bing(Department of Orthodondics,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine/College of Stomatology,Shanghai Jiao Tong University/National Center for Stomatology/National Clinical Research Center for Oral Diseases/Shanghai Key Laboratory of Stomatology/Shanghai Research Institute of Stomatology,Shanghai 200011,China)
出处
《医用生物力学》
北大核心
2025年第6期1655-1663,共9页
Journal of Medical Biomechanics
