摘要
目的通过数值仿真和实验测试,量化不同头部左倾角度下各半规管协同作用对前庭眼反射功能的影响,为临床评估前庭半规管功能提供了有效的理论分析方法。方法建立真实的人双耳半规管数值模型,通过流固耦合数值模拟不同左倾头位下(0°、15°、30°、45°、60°、70°、80°和90°)嵴顶的生物力学响应;同时,对志愿者进行不同左倾头位下的前庭眼反射实验,获取对应头位下志愿者的眼震慢相角速度。结果垂直眼震慢相角速度及其对应的嵴顶最大剪切应变随头部左倾角度的增加而增大,在头部向左倾斜大约70°位置达到最大值,然后逐渐下降;水平眼震慢相角速度及其对应的嵴顶最大剪切应变在头部向左倾斜0°位置最大,并随着头部左倾角度的增加而逐渐减小。结论基于双侧半规管嵴顶剪切应变的数值模拟结果,可定量阐释各个半规管兴奋/抑制对志愿者在不同左倾头位下眼震慢相角速度的综合效应。
Objective To quantitatively investigate the combined effects of individual semicircular canals on vestibulo-ocular reflex(VOR)function at various leftward head-tilt angles through numerical simulation and experimental validation,thereby providing an effective theoretical approach for the clinical assessment of semicircular canal function.Methods A realistic numerical model of the bilateral semicircular canals was established.Fluid-structure interaction simulations were conducted to analyze the biomechanical responses of the cupula under different left-tilted head positions(0°,15°,30°,45°,60°,70°,80°,and 90°).Additionally,VOR experiments were performed on volunteers under different left-tilted head positions to obtain the corresponding slow-phase eye velocities.Results Both vertical and horizontal slow-phase eye velocities,along with the corresponding maximum shear strains of the cupula,increased as the leftward head-tilt angle increased.Vertical slow-phase velocities and maximum shear strains peaked at approximately a 70°left-tilt angle and then gradually decreased.In contrast,horizontal slow-phase velocities and maximum shear strains reached their maxima at 0°left tilt and decreased progressively with increasing leftward tilt angles.Conclusions Numerical result of cupular shear strains in the bilateral semicircular canals quantitatively explain how combined excitation and inhibition of each canal affect the slow-phase eye velocities of volunteers under different left-tilted head positions.
作者
李运运
刘沐辰
刘含香
刘晓瑾
吴翔
于申
LI Yunyun;LIU Muchen;LIU Hanxiang;LIU Xiaojin;WU Xiang;YU Shen(Medical Equipment Management Department,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221006,Jiangsu,China;School of Medical Imaging,Xuzhou Medical University,Xuzhou 221004,Jiangsu,China;State Key Laboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,Dalian 116024,Liaoning,China)
出处
《医用生物力学》
北大核心
2025年第6期1623-1630,共8页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(12172082,11772087)
徐州医科大学优秀人才启动基金项目(D2021062)。
关键词
数值仿真
流固耦合
头部左倾角
半规管
前庭眼反射
numerical simulation
fluid-structure interaction
head left-tilt angles
semicircular canals
vestibuloocular reflex
