摘要
结直肠癌(colorectal cancer, CRC)是全球高发的消化道恶性肿瘤,其病理进程不仅与肠道微生态失衡高度相关,越来越多的研究提示口腔微生态也在其中扮演着重要角色。新兴的“口-肠轴”理论为阐释微生物的跨器官调控提供了新视角。近期研究表明,消化链球菌属(Peptostreptococcus)作为口腔微生物群落的主要成员,其异常变化与CRC的发生发展在时间和空间维度上均存在关联,可能通过“口-肠轴”途径调控肠道微生态及CRC病理演进。本文回顾了口腔与肠道的微生态对话,分析了消化链球菌[如胃消化链球菌(P. stomatis)、厌氧消化链球菌(P. anaerobius)]与CRC之间的多维关联,包括其在不同临床特征的CRC患者中呈现的群体异质性,以及其在“腺瘤-癌”病理阶段的动态演变规律和空间分布特征。总结了消化链球菌通过促进肿瘤细胞增殖、诱导上皮-间充质转化、重塑肿瘤微环境等方式影响CRC病程的作用机制。此外,本文还进一步探讨了消化链球菌作为CRC预测标志物及治疗靶点的临床应用潜力,提出未来可开发针对口腔源性微生物的干预策略,以期激发研究者对该领域的研究兴趣并推动深入研究。
Colorectal cancer(CRC),a common malignant neoplasm of the digestive system globally,demonstrates pathological progression that is intricately linked not only to dysbiosis of the gut microbiota but also to the oral microbial ecosystem.The emerging concept of the“oral-gut axis”offers novel insights into the regulation of microbial interactions across different organs.Recent research indicates that Peptostreptococcus,a predominant genus within the oral microbiome,exhibits spatiotemporal correlations with the initiation and progression of CRC.This genus may influence intestinal microecological changes and CRC pathogenesis through the“oralgut axis”.We explore the microbial interactions between oral and intestinal ecosystems,examining the multidimensional associations between specific Peptostreptococcus species(such as P.stomatis and P.anaerobius)and CRC development.Key considerations include the population heterogeneity of these species among CRC patients with varying clinical profiles,their dynamic evolution during the adenoma-carcinoma sequence,and their spatial distribution across different pathological stages.We synthesize mechanistic evidence illustrating the role of Peptostreptococcus in promoting tumorigenesis by enhancing cancer cell proliferation,inducing epithelial-mesenchymal transition,and remodeling the tumor microenvironment.Additionally,this article assesses the clinical potential of Peptostreptococcus as predictive biomarkers and therapeutic targets for CRC.Finally,we propose future directions for the development of targeted microbial intervention strategies against oral-derived pathogens,with the aim of stimulating scientific interest and encouraging further investigation in this emerging research area.
作者
朱宇虹
郭战丽
李雪珂
旷歧轩
付西
蒋义芳
马琼
由凤鸣
郑川
ZHU Yuhong;GUO Zhanli;LI Xueke;KUANG Qixuan;FU Xi;JIANG Yifang;MA Qiong;YOU Fengming;ZHENG Chuan(TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,China;Department of Oncology,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,China;Cancer Institute,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,China)
出处
《微生物学报》
北大核心
2025年第12期5209-5227,共19页
Acta Microbiologica Sinica
基金
四川省科技厅自然科学基金(2024NSFSC1849)。
关键词
口-肠轴
结直肠癌
消化链球菌
作用机制
生物标志物
oral-gut axis
colorectal cancer
Peptostreptococcus
mechanism of action
biomarker
