摘要
支气管哮喘是儿童及成人常见的慢性气道炎症性疾病,目前治疗主要依赖于症状导向的个体化治疗及免疫调节,易反复发作。宗气循经络而行,通上下,贯五脏,络六腑,而巨噬细胞通过淋巴系统流转全身,宗气运转可能影响巨噬细胞的极化、再生,进而干预免疫代谢功能,故宗气(营卫之气)循环的实质可理解为巨噬细胞再循环过程。宗气外泄则亏虚,营卫之气失去统摄之力,当机体卫气不固,防御下降,且营气涵养不足,则巨噬细胞启动糖代谢重编程,调整供能方式,募集并诱发巨噬细胞向M1型过度极化,诱发气道炎症反应,加剧哮喘的发生。此外,宗气亏虚,水道不利,聚津成痰,蛰伏体内,同样在巨噬细胞极化过程中,M2型巨噬细胞过度激活,增加黏液分泌及肺组织纤维化,进而产生多种黏附因子,导致气道高反应性,形成慢性炎症微环境。
Bronchial asthma is a common chronic inflammatory airway disease in children and adults.Current treatment mainly relies on symptom oriented personalized therapy and immune regulation,and the disease tends to recur.Zong Qi circulates through the meridians,connecting the upper and lower parts of the body,linking the Five Zang and the Six Fu,while macrophages circulate throughout the body via the lymphatic system.The movement of Zong Qi may influence the polarization and regeneration of macrophages,thereby affecting immune metabolic function.Therefore,the circulation of Zong Qi(Ying Qi and Wei Qi)can be understood as the process of macrophage recirculation.When Zong Qi is deficient and leaks outward,the energy of Ying and Wei loses its regulatory ability.When the body's Wei Qi is unstable and defense decreases,and Ying Qi is insufficient,macrophages initiate glucose metabolism reprogramming to adjust energy supply,recruiting and inducing macrophages to excessively polarize toward the M1 type,triggering airway inflammation and exacerbating asthma.In addition,when Zong Qi is deficient and Fluid pathways are obstructed,accumulating Fluids form Phlegm,which may remain dormant in the body.Similarly,during macrophage polarization,overactivation of M2 type macrophages occurs,increasing mucus secretion and pulmonary tissue fibrosis,producing various adhesion factors,leading to airway hyperresponsiveness,and forming a chronic inflammatory microenvironment.
作者
余欢
蔡萌
王孟清
帅云飞
YU Huan;CAI Meng;WANG Mengqing;SHUAI Yunfei(The First Affiliated Hospital to Hunan University of Chinese Medicine,Changsha Hunan China 410007;Center of Paediatrics,Zhujiang Hospital,Southern Medical University,Guangzhou Guangdong China 510280)
出处
《中医学报》
2026年第1期72-78,共7页
Acta Chinese Medicine
基金
国家自然科学基金项目(82174437)
湖南省自然科学基金项目(2020JJ4478)
湖南省卫生健康委员会科研计划项目(20200289)
湖南中医药大学中医儿科学湖南省“双一流”学科建设项目(4912-0005001010)。
