摘要
目的:探讨扶正清解合剂治疗正气不足兼痰浊郁热证甲状腺功能亢进症患者的有效性与安全性。方法:选取2022年12月—2024年3月南平市人民医院接收的68例正气不足兼痰浊郁热证甲状腺功能亢进症患者,借助随机数字表法将其分为两组,各34例。对照组开展甲巯咪唑治疗,试验组在对照组基础上使用扶正清解合剂治疗。两组疗程均为3个月。对比两组临床疗效、中医证候积分、促甲状腺激素、甲状腺激素水平及不良反应。结果:试验组治疗总有效率高于对照组(P<0.05);治疗后,试验组中医证候积分低于对照组(P<0.05);治疗后,试验组促甲状腺激素高于对照组,游离三碘甲腺原氨酸与游离甲状腺素低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对正气不足兼痰浊郁热证甲状腺功能亢进症患者使用扶正清解合剂治疗效果确切,可有效改善患者临床症状及甲状腺激素水平,利于促进疾病转归,未明显增加不良反应发生。
Objective:To investigate the efficacy and safety of Fuzheng Qingjie Mixture in the treatment of patients with hyperthyroidism and deficiency of vital Qi combined with phlegm-turbidity and heat-stagnation syndrome.Method:A total of 68 patients with hyperthyroidism and deficiency of vital Qi combined with phlegmturbidity and heat-stagnation syndrome admitted to the Nanping People's Hospital from December 2022 to March 2024 were selected and divided into two groups by random number table method,with 34 cases in each group.The control group was treated with Thiamazole,while the experimental group was treated with Fuzheng Qingjie Mixture on the basis of the control group.The treatment courses for both groups were three months.The clinical treatment efficiency,traditional Chinese medicine syndrome scores,thyroid-stimulating hormone,thyroid hormone levels,and adverse reactions were compared between the two groups.Result:The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).After the treatment,the traditional Chinese medicine syndrome score of the experimental group was lower than that of the control group(P<0.05).After treatment,the thyroid stimulating hormone in the experimental group was higher than that in the control group,while the free triiodothyronine and free thyroxine were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Fuzheng Qingjie Mixture is effective in the treatment of hyperthyroidism with deficiency of vital Qi combined with phlegm-turbidity and heat-stagnation syndrome,which can effectively improve the clinical symptoms and thyroid hormone levels of patients,promote the outcome of the disease,and does not significantly increase the occurrence of adverse reactions.
作者
徐晓薇
赖丽娟
姜建珍
叶明华
XU Xiaowei;LAI Lijuan;JIANG Jianzhen;YE Minghua(Endocrinology Department of Nanping People's Hospital,Nanping 353000,China;不详)
出处
《中国医学创新》
2025年第36期1-4,共4页
Medical Innovation of China
基金
南平市科技计划项目(N2023J026)。
关键词
甲状腺功能亢进症
正气不足
痰浊郁热证
扶正清解合剂
甲巯咪唑
Hyperthyroidism
Deficiency of vital Qi
Phlegm-turbidity and heat-stagnation syndrome
Fuzheng Qingjie Mixture
Thiamazole
