摘要
目的:观察巴氯芬配合A型肉毒毒素对脑卒中后肌张力障碍患者肌张力恢复情况及运动功能的影响。方法:选择2022年1月—2024年8月合肥市第一人民医院收治的100例脑卒中后肌张力障碍患者,随机分为两组,各50例。观察组予以巴氯芬片配合A型肉毒毒素治疗,对照组予以巴氯芬片口服治疗,两组治疗周期均为16~20周。比较两组临床疗效、肌张力恢复情况、运动功能改善情况及安全性。结果:治疗后,观察组总有效率高于对照组(P<0.05)。治疗后,观察组改良Ashworth量表(modified Ashworth scale,MAS)分级优于对照组(P<0.05);治疗后,观察组Fugl-Meyer评估量表(Fugl-Meyer assessment scale,FMA)各项评分高于对照组(P<0.05);两组均未出现明显不良反应。结论:巴氯芬配合A型肉毒毒素治疗脑卒中后肌张力障碍效果显著,可显著改善患者肌张力及运动功能,且无不良反应发生,安全性较高。
Objective:To observe the effect of Baclofen combined with Botulinum Toxin Type A on muscle tone recovery and motor function in patients with dystonia after stroke.Method:A total of 100 patients with dystonia after stroke admitted to the First People's Hospital of Zunyi from January 2022 to August 2024 were selected and randomly divided into two groups,with 50 cases in each group.The observation group was treated with Baclofen Tablets combined with Botulinum Toxin Type A,while the control group was treated with oral Baclofen Tablets.The treatment cycle for both groups was 16 to 20 weeks.The clinical efficacy,muscle tone recovery,improvement of motor function and safety of the two groups were compared.Result:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the modified Ashworth scale(MAS)grade of the observation group was better than that of the control group(P<0.05).After treatment,the score of the Fugl-meyer assessment scale(FMA)of each item in the observation group were higher than those in the control group(P<0.05).No obvious adverse reactions occurred in either group.Conclusion:Baclofen combined with Botulinum Toxin Type A is effective in the treatment of dystonia after stroke,which can significantly improve the muscle tone and motor function of patients,without adverse reactions,and has high safety.
作者
曹光宇
CAO Guangyu(Department of Neurology,the First People's Hospital of Zunyi,Zunyi 563003,China)
出处
《中国医学创新》
2025年第35期98-101,共4页
Medical Innovation of China
