摘要
目的:探究肠炎宁颗粒联合蒙脱石散治疗小儿轮状病毒性肠炎的效果。方法:选取2023年8月—2025年3月于连云港市妇幼保健院就诊的122例轮状病毒性肠炎患儿,根据随机数字表法分为对照组(n=61,蒙脱石散治疗)和观察组(n=61,在对照组基础上联合肠炎宁颗粒治疗)。对比两组血清炎性因子水平、肠道菌群计数水平及临床疗效。结果:治疗5 d后,与对照组相比,观察组C反应蛋白、肿瘤坏死因子-α及白细胞介素-6水平较低(P<0.05);治疗5 d后,与对照组相比,观察组嗜酸乳杆菌及双歧杆菌计数水平较高(P<0.05),大肠埃希菌计数水平较低(P<0.05);与对照组相比,观察组治疗总有效率较高(P=0.015)。结论:肠炎宁颗粒联合蒙脱石散治疗小儿轮状病毒性肠炎的效果较好,可降低血清炎性因子水平,调节肠道菌群。
Objective:To study the effect of Changyanning granules combined with montmorillonite powder in treatment of pediatric rotavirus enteritis.Methods:A total of 122 children with rotavirus enteritis who visited Lianyungang Maternal and Child Health Hospital from August 2023 to March 2025 were selected.They were divided into a control group(n=61,treated with montmorillonite powder)and an observation group(n=61,treated with Changyanning granules on the basis of control group)using a random number table method.The serum inflammatory factor levels,intestinal flora count,and clinical efficacy of the two groups were compared.Result:After 5 days of treatment,compared with the control group,the levels of C-reactive protein,tumor necrosis factor-αand interleukin-6 in the observation group were lower(P<0.05).After 5 days of treatment,compared with the control group,the counts of Lactobacillus acidophilus and Bifidobacterium in the observation group were higher(P<0.05),and the count of Escherichia coli was lower(P<0.05).Compared with the control group,the total effective rate of treatment in the observation group was higher(P=0.015).Conclusion:Changyanning granules combined with montmorillonite powder has a good effect in the treatment of pediatric rotavirus enteritis,and can reduce the levels of serum inflammatory factors and regulate intestinal flora.
作者
尹闯
Yin Chuang(Department of Pediatrics,Lianyungang Maternal and Child Health Hospital,Lianyungang 222000,Jiangsu Province,China)
出处
《中外医药研究》
2025年第31期99-101,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
轮状病毒性肠炎
肠炎宁颗粒
蒙脱石散
炎性因子
肠道菌群
Rotavirus enteritis
Changyanning granules
Montmorillonite powder
Inflammatory factor
Intestinal fora
