摘要
目的:分析莫西沙星序贯治疗老年社区获得性肺炎(CAP)的效果。方法:采用双色球法将陇南市第一人民医院2021年1月—2024年1月收治的140例老年CAP患者分为对照组(70例)和研究组(70例)。对照组给予左氧氟沙星治疗,研究组给予莫西沙星治疗。对比两组临床疗效、炎性因子水平、肺功能及免疫指标。结果:与对照组相比,研究组治疗总有效率较高(P=0.013);与对照组相比,研究组治疗后白细胞介素-6、超敏C反应蛋白、肿瘤坏死因子-α水平较低(P<0.001);与对照组相比,研究组治疗后用力肺活量、第1秒用力呼气容积及第1秒用力呼气容积/用力肺活量较高(P<0.001);与对照组相比,研究组治疗后CD3^(+)与CD4^(+)水平较高(P<0.001),CD8^(+)水平较低(P<0.001)。结论:莫西沙星序贯治疗可降低CAP患者的炎性因子水平,改善肺功能,促进免疫功能恢复,效果较好。
Objective:To analyze the effect of moxifloxacin sequential therapy for community-acquired pneumonia(CAP)in the elderly.Methods:A total of 140 elderly patients with CAP admitted to the First People's Hospital of Longnan from January 2021 to January 2024 were divided into the control group(70 cases)and the study group(70 cases)according to the two-color ball method.The control group was treated with levofloxacin,and the study group was treated with moxifloxacin.The two groups were compared in terms of clinical efficacy,inflammatory factor levels,lung function and immune indexes.Results:Compared with the control group,the total effective rate of treatment in the study group was higher(P=0.013).Compared with the control group,the levels of interleukin-6,high-sensitivity C-reactive protein,and tumor necrosis factor-αin the study group after treatment were lower(P<0.001).Compared with the control group,the forced vital capacity,forced expiratory volume in one second,and forced expiratory volume in one second/forced vital capacity in the study group after treatment were higher(P<0.001).Compared with the control group,the levels of CD3^(+)and CD4^(+)in the study group after treatment were higher(P<0.001),and the level of CD8^(+)was lower(P<0.001).Conclusion:Moxifloxacin sequential therapy can reduce the levels of inflammatory factors,enhance lung function,and promote the recovery of immune function of CAP patients,and has a good effect.
作者
刘婷
Liu Ting(The First People's Hospital of Longnan,Longnan 746000,Gansu Province,China)
出处
《中外医药研究》
2025年第31期46-48,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
社区获得性肺炎
老年
莫西沙星
左氧氟沙星
炎性因子
肺功能
免疫功能
Community-acquired pneumonia
Elderly
Moxifloxacin
Levofloxacin
Inflammatory factors
Pulmonary function
Immune function
