摘要
目的探究血清C-反应蛋白(CRP)/淋巴细胞与单核细胞比值(LMR)、降钙素原(PCT)/乳酸(Lac)与脓毒症患者病情严重程度的相关性。方法选取2021年1月至2025年1月于宁夏医科大学总医院心脑血管病医院重症监护病房收治的196例脓毒症患者作为研究对象,根据是否发生脓毒性休克分为脓毒症组(n=142)和脓毒症休克组(n=54)。收集脓毒症患者一般资料,评估入院后24 h内的SOFA评分、APACHEⅡ评分,并检测血清CRP、LMR、PCT、Lac水平。Pearson法分析血清CRP/LMR、PCT/Lac与SOFA评分、APACHEⅡ评分的相关性。多因素Logistic回归分析影响脓毒症患者发生休克的因素。结果脓毒症休克组患者APACHEⅡ评分、SOFA评分、CRP/LMR、PCT/Lac均显著高于脓毒症组,差异有统计学意义(P<0.05)。SOFA评分>10分的患者CRP/LMR、PCT/Lac显著高于SOFA评分6~10分的患者,SOFA评分6~10分的患者显著高于SOFA评分1~5分的患者,差异有统计学意义(P<0.05)。脓毒症患者血清CRP/LMR、PCT/Lac与SOFA评分、APACHEⅡ评分均呈正相关(P<0.001)。SOFA评分、APACHEⅡ评分、CRP/LMR、PCT/Lac均是影响脓毒症患者发生休克的重要因素(P<0.05)。结论血清CRP/LMR、PCT/Lac与脓毒症患者病情严重程度具有相关性,且是影响脓毒症患者发生休克的重要因素。
Objective To explore the correlation of serum C-reactive protein(CRP)/lymphocyte to monocyte ratio(LMR),procalcitonin(PCT)/lactate(Lac)with the severity of sepsis in patients.Methods A total of 196 patients with sepsis were admitted to the Intensive Care Unit of the Cardiovascular and Cerebrovas-cular Disease Hospital at Ningxia Medical University General Hospital from January 2021 to January 2025.These patients were selected as research subjects and were divided into the sepsis group(n=142)and the septic shock group(n=54)based on the presence of septic shock.General data of the sepsis patients were collected,and the SOFA score and APACHEⅡscore were assessed within 24 h of admission,and serum CRP,LMR,PCT and Lac levels were detected.The Pearson method was used to analyze the correlation between serum CRP/LMR,PCT/Lac,and the SOFA score and APACHEⅡscore.Multifactorial logistic regression was used to ana-lyze the factors affecting the occurrence of shock in septic patients.Results The APACHEⅡscore,SOFA score,CRP/LMR,and PCT/Lac of patients in the septic shock group were significantly higher than those in the sepsis group(P<0.05).CRP/LMR and PCT/Lac of patients with a SOFA score of>10 was significantly higher than those with a SOFA score of 6~10,and those with a SOFA score of 6~10 was significantly higher than those with a SOFA score of 1~5 score patients,the difference was statistically significant(P<0.05).Serum CRP/LMR and PCT/Lac were positively correlated with SOFA score and APACHEⅡscore in patients with sepsis(P<0.001).SOFA score and APACHEⅡscore,CRP/LMR,and PCT/Lac were all significant factors influencing the occurrence of shock in septic patients,the difference was statistically significant(P<0.05).Conclusion Se-rum CRP/LMR and PCT/Lac ratios correlate with the severity of sepsis and serve as independent predictors of septic shock,demonstrating potential for clinical risk stratification.
作者
杨波
王东磊
李磊
YANG Bo;WANG Donglei;LI Lei(ICU,Cardio-Cerebrovascular Hospital,General Hospital of Ningxia Medical University,Yinchuan,Ningxia,China,750004)
出处
《分子诊断与治疗杂志》
2025年第12期2302-2305,共4页
Journal of Molecular Diagnostics and Therapy
基金
宁夏自然科学基金项目(2023AAC03581)。
