摘要
目的分析MRI联合血清前列腺特异性抗原(PSA)、PSA密度(PSAD)、游离PSA(fPSA)与总PSA(tPSA)的比值(f/tPSA)对早期前列腺癌(PCa)诊断价值。方法回顾性选取靖江市人民医院2022年月至2025年1月收治疑似PCa的122例患者为研究对象,依据是否确诊PCa分为PCa组和非PCa组。所有研究对象入院时均接受彩色多普勒超声、MRI相关检查及血清PSA、PSAD、f/tPSA等相关实验室检查。比较两组研究对象MRI参数及血清PSA、PSAD、f/tPSA,分析上述指标在PCa早期诊断中的价值。结果PCa组前列腺体积、表观弥散系数(ADC)、相对ADC(rADC)值均大于非PCa组,差异有统计学意义(P<0.05);PCa组PSA、PSAD均高于非PCa组,f/tPSA低于非PCa组,差异有统计学意义(P<0.05);多因素Logistic回归分析,结果显示,rADC、PSA、PSAD及f/tPSA为PCa发生的独立相关因素(P<0.05);受试者工作特征曲线(ROC)分析显示,rADC、PSA、PSAD及f/tPSA联合诊断的AUC值为0.941(0.884~0.976),显著高于单独诊断(P<0.05)。结论MRI参数联合血清PSA、PSAD、f/tPSA对PCa早期的诊断具有显著的临床价值,值得临床推广。
Objective To analyze the diagnostic value of magnetic resonance imaging(MRI)com-bined with serum prostate-specific antigen(PSA),PSA density(PSAD),and free/total PSA(f/tPSA)for early prostate cancer(PCa).Methods A total of 122 patients with suspected PCa who were admitted to Jingjiang People's Hospital from 2022 to January 2025 were retrospectively selected and divided into the PCa group and the non-PCa group.Upon admission,all patients received color Doppler ultrasound examination,MRI-related examinations,and laboratory testing for serum PSA,PSAD,and f/tPSA.MRI parameters,serum PSA,PSAD,and f/tPSA were compared between the two groups.The value of the above indicators in diagnosing early PCa was analyzed.Results Prostate volume,apparent diffusion coefficient(ADC)value,and relative ADC(rADC)value of the PCa group were greater than those of the non-PCa group,with statistically signifi-cant differences(P<0.05).PSA level and PSAD of the PCa group were higher than those of the non-PCa group,while f/tPSA was lower than that of the non-PCa group,with statistically significant differences(P<0.05).Mul-tivariate logistic regression analysis revealed that rADC,PSA,PSAD,and f/tPSA were independent factors in-fluencing the occurrence of PCa(P<0.05).The receiver operator characteristic(ROC)analysis showed that the area under the curve(AUC)of joint diagnosis with rADC,PSA,PSAD,and f/tPSA was 0.941(0.884~0.976),which was significantly greater than that of separate diagnosis(P<0.05).Conclusion The combination of MRI parameters,serum PSA,PSAD and f/tPSA demonstrates high clinical value in diagnosing early PCa and is wor-thy of clinical promotion.
作者
陈新国
陈蕾
肖伟
高峰
CHEN Xinguo;CHEN Lei;XIAO Wei;GAO Feng(Imaging Department,Jingjiang People's Hospital,Taizhou,Jiangsu,China,214500)
出处
《分子诊断与治疗杂志》
2025年第12期2292-2294,2298,共4页
Journal of Molecular Diagnostics and Therapy
基金
江苏省医药卫生科技发展计划项目(20220533)。
