摘要
目的探究血清白细胞介素-33(IL-33)、巨噬细胞集落刺激因子(M-CSF)、卵泡抑素样蛋白1(FSTL1)对宫颈上皮内瘤变(CIN)患者病变为早期宫颈癌(CC)的鉴别价值。方法选取2023年2月至2024年8月在盐城市第一人民医院就诊的CIN患者77例作为CIN组,CC患者25例作为CC组;另选取同期体检健康女性志愿者82例作为正常组;以ELISA检测血清IL-33、M-CSF、FSTL1水平;对比正常组、CIN组、CC组患者血清IL-33、M-CSF、FSTL1水平;比较CIN组、CC组患者基础资料,筛选发生CC病变的单因素;采用Pearson法分析本研究患者血清IL-33、M-CSF、FSTL1水平之间的相关性;使用多因素Logistic回归模型分析CIN发展至CC的影响因素;采用ROC分析血清IL-33、M-CSF、FSTL1对CIN及CC的鉴别价值。结果与正常组相比,CIN组与CC组血清IL-33、M-CSF水平升高(P<0.05),CC组高于CIN组(P<0.05);而FSTL1水平降低(P<0.05),CC组低于CIN组(P<0.05);CC组患者初次性生活年龄<18岁、性伴侣个数≥2个占比以及性生活频率大于CIN组(P<0.05);血清IL-33与血清M-CSF水平呈正相关(r=0.711,P<0.001),二者与血清FSTL1水平均呈负相关(r=–0.582、–0.404,P<0.001);IL-33、M-CSF、FSTL1均是发生CC病变的影响因素(P<0.05),可用于CIN及CC的鉴别,且三者联合鉴别价值更高(P<0.05)。结论血清IL-33、M-CSF在CC患者体内升高,FSTL1水平则在CC患者体内降低,三者联合在鉴别CIN及CC方面具有较高价值。
Objective To explore the differential value of serum IL-33,M-CSF,and FSTL1 in cervical intraepithelial neoplasia(CIN)and early cervical cancer(CC).Methods From February 2023 to August 2024,77 patients with CIN who visited Yancheng First People's Hospital were used as the CIN group,and 25 patients with CC were used as the CC group.Another 82 healthy female volunteers who experienced physical check ups were as the normal group.ELISA was used to detect serum IL-33,M-CSF,and FSTL1.The serum IL-33,M-CSF,and FSTL1 were compared among the normal group,CIN group,and CC group patients,the basic data of patients in the CIN group and CC group were compared,and the single factor causing CC lesions was screened.Pearson method was used to analyze the correlation between serum IL-33,M-CSF,and FSTL1 levels in the patients of this study.Multiple Logistic regression model was used to analyze the influencing factors of CIN progression to CC.ROC was used to analyze the differential value of serum IL-33,M-CSF,and FSTL1 for CIN and CC.Results Compared with the normal group,the serum IL-33 and M-CSF were higher in the CIN group and CC group(P<0.05),and those in CC group were higher than those in CIN group(P<0.05).The FSTL1 decreased(P<0.05),and that in CC group was lower than that in CIN group(P<0.05).The proportions of age of first sexual intercourse<18 years old and the sexual partners≥2,and the frequency of sexual intercourse in the CC group were higher than those in the CIN group(P<0.05).Serum IL-33 was positively correlated with serum M-CSF(r=0.711,P<0.001),and both were negatively correlated with serum FSTL1(r=—0.582,-0.404,P<0.001).IL-33,M-CSF,and FSTL1 were all influencing factors for the occurrence of CC lesions(P<0.05),which could be used for the differentiation between CIN and CC,and the combined value of the three was higher(P<0.05).Conclusion Serum IL-33 and M-CSF are elevated in CC patients,while FSTL1 is reduced in CC patients.The combination of the three has high value in distinguishing CIN and CC.
作者
成艳
杨朝晖
施蕾
CHENG Yan;YANG Zhaohui;SHI Lei(Department of Obstetrics and Gynecology,The First People's Hospital of Yancheng(Yancheng No.1 People's Hospital,Affiliated Hospital of Medical School,Nanjing University),Yancheng,Jiangsu 224000,China)
出处
《中国优生与遗传杂志》
2025年第10期2192-2196,共5页
Chinese Journal of Birth Health & Heredity
