摘要
经颅磁刺激(TMS)虽广泛应用于神经调控,但传统TMS难以兼顾刺激深度和聚焦性。时间干涉经颅磁刺激(TI-TMS)能增加刺激深度同时减小聚焦面积,但其研究主要以仿真分析为主,关于系统构建及其在啮齿类动物深部脑区的有效性研究尚显不足。为此,本研究基于真实小鼠头模型进行有限元仿真并构建TI-TMS系统,结合电生理实验记录小鼠腹侧海马(vHPC)的局部场电位,分析刺激后θ节律功率谱密度(PSD)变化及θ-γ节律相位幅值耦合(PAC)强度的变化。结果显示,TI-TMS可增强θ节律能量并提高θ-γ节律PAC强度,表明其能够有效刺激小鼠深部脑区。本研究构建的TI-TMS系统可实现对vHPC深部脑区的有效刺激,为其在脑深部神经调控中的应用提供了依据。
Although transcranial magnetic stimulation(TMS)is widely used in neuromodulation,conventional TMS struggles to achieve both depth and focal specificity.Temporal interference TMS(TI-TMS)offers a promising approach to enhance stimulation depth while reducing the focal area;however,current research remains largely simulation-based,with limited studies on system implementation and experimental validation in rodent deep brain regions.To address this,we developed a TI-TMS system based on a realistic mouse head model using finite element simulation.Electrophysiological recordings of local field potentials(LFPs)in the ventral hippocampal(vHPC)formation were performed to evaluate changes inθrhythm power spectral density(PSD)andθ-γphase-amplitude coupling(PAC)following stimulation.The results demonstrated that TI-TMS enhancedθrhythm power and strengthenedθ-γPAC,indicating effective modulation of deep brain regions.This study establishes a functional TI-TMS system capable of effectively stimulating deep vHPC,providing an experimental basis for its application in precise neuromodulation of subcortical brain areas.
作者
崔超
王亭宇
张延清
郑卫然
徐桂芝
CUI Chao;WANG Tingyu;ZHANG Yanqing;ZHENG Weiran;XU Guizhi(School of Electrical Engineering,Hebei University of Technology,Tianjin 300401,P.R.China;State Key Laboratory of Smart Power Distribution Equipment and System,Hebei University of Technology,Tianjin 300401,P.R.China;Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health,Hebei University of Technology,Tianjin 300130,P.R.China)
出处
《生物医学工程学杂志》
北大核心
2025年第6期1099-1106,共8页
Journal of Biomedical Engineering
基金
国家自然科学基金国际重点合作项目(52320105008)
国家重点研发计划(2022YFC2402203)。
关键词
时间干涉经颅磁刺激
系统设计
电生理验证
Temporal-interference magnetic stimulation
System design
Electrophysiological validation
