摘要
[目的]研发高活性三氟乙基硫醚/亚砜类杀螨化合物。[方法]以sulfiflumin为先导化合物,引入杀虫(螨)剂中常见的嘧啶结构,设计并合成了15个N-嘧啶三氟乙基硫醚/亚砜苯胺类化合物,并对其进行杀螨活性测试。[结果]在100 mg/L质量浓度下,该系列化合物对朱砂叶螨和二斑叶螨均有一定的杀螨活性,且对二斑叶螨的活性远高于对朱砂叶螨的活性,大部分化合物对二斑叶螨的致死率高于90%。[结论]所合成化合物具有较好的杀螨活性,为三氟乙基硫醚/亚砜衍生物的设计和改造提供研究思路。
[Aims]This study aims to generate trifluoroethyl sulfide/sulfoxide compounds with excellent acaricidal activity.[Methods]The lead compound sulfiflumin was modified by introducing the pyrimidine structure commonly found in insecticides/acaricides.Fifteen N-pyrimidine trifluoroethyl sulfide/sulfoxide aniline compounds were designed and synthesized,and their acaricidal activities were tested.[Results]The synthesized compounds had certain acaricidal activity against Tetranychus urticae and T.cinnabarinus at the dosage of 100 mg/L.The activity against T.urticae is much higher than that of T.cinnabarinus and the mortality of most compounds against T.urticae was higher than 90%.[Conclusions]The synthesized compounds with good acaricidal activity provide a guideline for the design of trifluoroethyl sulfide/sulfoxide compounds.
作者
王佳鑫
蔡胜梅
田平义
包如胜
刘祈星
周海峰
WANG Jiaxin;CAI Shengmei;TIAN Pingyi;BAO Rusheng;LIU Qixing;ZHOU Haifeng(Research Center of Green Pharmaceutical Technology and Process,Hubei Key Laboratory of Natural Products Research and Development,College of Biological and Pharmaceutical Sciences,China Three Gorges University,Yichang 443002,Hubei,China;Hangzhou Electrochemical Group Auxiliary Chemical Co.,Ltd.,Hangzhou 311228,China;Taizhou Key Laboratory of Green Agrochemicals Development,Synwill Co.,Ltd.,Taizhou 318000,Zhejiang,China)
出处
《农药》
北大核心
2025年第12期868-875,共8页
Agrochemicals
基金
顺毅股份有限公司研发项目(SDHZ2021215)
国家自然科学基金(22278244)。
关键词
三氟乙基硫醚/亚砜
嘧啶
杀螨活性
合成
trifluoroethyl sulfide/sulfoxide
pyrimidine
acaricidal activity
synthesis
