摘要
目的:基于血清肺炎支原体(MP)IgM抗体(MP-IgM)、MP-IgG表达探讨儿童肺炎支原体肺炎(MPP)的病情预测及诊治策略。方法:选取2024年4-10月于我院就诊的120例MPP患儿(疾病组)和100例体检健康的儿童(健康组),疾病组分为重度组52例与轻度组68例。磁微粒化学发光法分析血清MP-IgM、MP-IgG表达水平,并以受试者工作特征(ROC)分析其对重症MPP的预测价值。结果:疾病组血清MP-IgM、MP-IgG水平高于健康组,且重度组高于轻度组(P均<0.05)。重度组发热时间、C反应蛋白高于轻度组,氧合指数低于轻度组(P均<0.05)。血清MP-IgM、MP-IgG联合预测重症MPP的AUC高于单独预测(P<0.05)。结论:血清MP-IGM、MP-IGG表达水平是预测重症MPP的高效生物学标志物,且联合预测效能更高;通过量化MP-IgM、MP-IgG预测效能,可根据疾病严重程度制定合理的分级干预方案,为个体化治疗提供参考。
Objective:To explore the disease prediction and treatment strategy for Mycoplasma pneumoniae pneumonia in children based on serum M.pneumoniae(MP)-IgM antibody(MP-IgM)and MP-IgG expression.Methods:From Apr.to Oct.2024,totally 120 children with MPP admitted into our hospital(disease group)and 100 healthy children with physical examination(healthy group)were extracted.The disease group was assigned into severe group(52 cases)and mild group(68 cases).The expression levels of MP-IgM and MP-IgG were analyzed by using magnetic particle chemiluminescence method,and the predictive value of the indicators for severe MPP was evaluated by receiver operator characteristics(ROC)analysis.Results:The levels of MP-IgM and MP-IgG in the disease group were higher than those in the healthy group,and the severe group was higher than the mild group(P<0.05).The duration of fever and C-reactive protein levels in the severe group were higher than those in the mild group,while the oxygenation indicator in the severe group was lower than that in the mild group(P<0.05).The AUC of the combined prediction of MP-IgM and MP-IgG for severe MPP was higher than that of individual prediction(P<0.05).Conclusion:The expression levels of MP-IgM and MP-IgG are highly effective biological markers for predicting severe MPP.Moreover,the combined effect of the two is even more significant.By quantifying the predictive efficacy of MP-IgM and MP-IgG,a reasonable grading intervention regimen for the severity of disease can be formulated,providing a scientific basis for individualized treatment.
作者
舒玲
王宏勇
李蓬
Shu Ling;Wang Hongyong;Li Peng(The First People’s Hospital of Tianmen,Hubei Tianmen 431700,China)
出处
《儿科药学杂志》
2026年第1期30-33,共4页
Journal of Pediatric Pharmacy
基金
湖北省卫健委卫生健康科研项目,编号WJ2021M045。
关键词
肺炎支原体肺炎
儿童
肺炎支原体IGM抗体
肺炎支原体IgG抗体
病情预测
诊治策略
Mycoplasma pneumoniae pneumonia
children
Mycoplasma pneumoniae-IgM antibody
Mycoplasma pneumoniae-IgG antibody
disease prediction
treatment strategy
