摘要
目的通过比较国家集中采购药品和原研药品注射用头孢呋辛钠在妇产科围手术期预防用药的有效性、安全性,以求找出更安全、有效、经济的预防用药方案,为围手术期预防感染用药提供依据。方法本研究采用回顾性分析方法,抽取某院妇产科围手术期使用注射用头孢呋辛钠预防感染的手术患者电子病历数据,使用SPSS 27.0软件对两组患者基线信息进行进行倾向性评分匹配,以确保两组患者在接受集采组和进口组头孢呋辛钠治疗时基线特征的可比性。分析两组药品预防术后感染的有效性、安全性、经济性指标。结果集采组和原研组头孢呋辛钠的有效性、不良反应发生率均无显著性差异(P>0.05)。两组患者经济性指标有显著性差异(P<0.05),相较于原研组,集采组费用显著减少。结论在围手术期预防应用注射用头孢呋辛钠的妇产科患者中,集采和原研药物预防术后感染的有效性及安全性无统计学差异。在预防术后感染方面,集采药物的花费更少。在确保药品质量与疗效的前提下,推广使用集采药品头孢呋辛钠不仅能够降低患者的经济负担,还有助于优化医疗资源配置。
OBJECTIVE To compare the efficacy and safety of national centralized procurement drugs and original research drugs(cefuroxime sodium for injection)in the perioperative period of gynecology and obstetrics,in order to identify a safer,more effective,and more economical prophylactic regimen and provide evidence for perioperative prophylactic antibiotic use.METHODS This study employed a retrospective analysis method,extracting electronic medical records of surgical patients who used cefuroxime sodium for injection for perioperative infection prophylaxis in the gynecology and obstetrics department of a hospital.Propensity score matching was conducted using SPSS 27.0 software to ensure comparability of baseline characteristics between the centralized procurement group and the original research group.The efficacy,safety,and cost-effectiveness of the two drugs in preventing postoperative infections were analyzed.RESULTS There were no significant differences in the efficacy and incidence of adverse reactions between the centralized procurement group and the original research group(P>0.05).However,significant differences were observed in the costffectiveness indicators(P<0.05),with the centralized procurement group incurring significantly lower costs compared to the original research group.CONCLUSION In gynecology and obstetrics patients receiving cefuroxime sodium for injection for perioperative prophylaxis,there were no statistical differences in efficacy and safety between the centralized procurement and original research drugs.The centralized procurement drug was more cost-effective in preventing postoperative infections.Promoting the use of centralized procurement cefuroxime sodium,while ensuring drug quality and efficacy,can not only reduce the economic burden on patients but also optimize the allocation of medical resources.
作者
孙静雯
林添
蔡鸿福
林碧娟
刘茂柏
曾晓芳
SUN Jing-wen;LIN Tian;CAI Hong-fu;LIN Bi-juan;LIU Mao-bai;ZENG Xiao-fang(School of Pharmacy,Fujian Medical University,Fuzhou 350122,China;Fujian Medical University Union Hospital,Fuzhou 350001,China)
出处
《海峡药学》
2025年第11期56-61,共6页
Strait Pharmaceutical Journal
基金
吴阶平医学基金项目(编号:320.6750.2023-06-73)。
