摘要
目的探究血液滤过吸附(Supra-HFR)体内置换液生成再输注与全血灌流对维持性血液透析患者的临床疗效比较。方法选取2023年5月至2024年5月本院收治的180例维持性血液透析患者为研究对象,采用随机数字表法将患者分成研究组和对照组,每组各90例。研究组患者采用Supra-HFR体内置换液生成再输注治疗,对照组患者采用全血灌流治疗。比较两组患者治疗前后的各项微炎症因子、血脂水平、临床状态及残余肾功能(RRF)。结果治疗后两组患者的白细胞介素(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均较治疗前降低(均P<0.05),且研究组患者的IL-6、TNF-α和CRP水平均低于对照组(均P<0.05)。治疗后,两组患者的三酰甘油(TG)水平均较治疗前降低,且研究组的TG水平低于对照组(P<0.05)。治疗后,两组患者的临床状态各项维度评分均较治疗前升高,且研究组的各项评分均高于对照组(均P<0.05)。干预后两组患者的RRF均较干预前降低,但研究组的RRF水平高于对照组(均P<0.05)。结论Supra-HFR体内置换液生成再输注能有效改善维持性血液透析患者机体的微炎症状态以及血脂水平,保护RRF,值得临床推广与应用。
Objective To compare the clinical application of Supra-hemodiafiltration with endogenous reinfusion(Supra-HFR)replacement fluid generation and reinfusion with whole blood perfusion in maintenance hemodialysis patients.Methods A total of 180 patients with maintenance hemodialysis from May 2023 to May 2024 were selected as research subjects.They were divided into the study group and the control group using a random number table method,with 90 patients in each group.The study group was treated with Supra-HFR replacement fluid generation and reinfusion,while the control group was treated with whole blood perfusion.Microinflammatory factors,lipid levels,clinical status and residual renal function(RRF)were compared in two groups.Results After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-alphain(TNF-α)and C-reactive protein(CRP)in both groups were lower than those before treatment(all P<0.05),and the levels of IL-6,TNF-α and CRP in the study group were lower than those in the control group(all P<0.05).After treatment,the triglyceride(TG)levels in both groups decreased compared with those before treatment,and the TG level in the study group was lower than that in the control group(P<0.05).The scores of all dimensions of clinical status in both groups increased after treatment,and all scores in the study group were higher than those in the control group(all P<0.05).After intervention,the RRF of patients in both groups was lower than that before intervention,but the RRF level in the study group was higher than that in the control group(all P<0.05).Conclusions Supra-HFR replacement fluid generation and reinfusion can effectively improve the microinflammatory state and blood lipid level in maintenance hemodialysis patients,and protect RRF,which is worthy of promotion and application.
作者
马国英
王艳
鹿岑丹
伍铭艳
Ma Guoying;Wang Yan;Lu Cendan;Wu Mingyan(Department of Nephrology,Qiandongnan Prefecture People's Hospital of Guizhou Province,Qiandong,556000,China)
出处
《国际泌尿系统杂志》
2025年第6期155-159,共5页
International Journal of Urology and Nephrology
基金
2022年度贵州省卫生健康委科学技术基金项目(gzwkj2022-061)。
